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Subcutaneous drug delivery: An evolving enterprise.
Sci Transl Med. 2017 Aug 30;9(405):eaaf9166. doi: 10.1126/scitranslmed.aaf9166.
Sci Transl Med. 2017.
PMID: 28855399
Review.
Optimizing the Bioavailability of Subcutaneously Administered Biotherapeutics Through Mechanochemical Drivers.
Collins DS, Kourtis LC, Thyagarajapuram NR, Sirkar R, Kapur S, Harrison MW, Bryan DJ, Jones GB, Wright JM.
Collins DS, et al. Among authors: thyagarajapuram nr.
Pharm Res. 2017 Oct;34(10):2000-2011. doi: 10.1007/s11095-017-2229-9. Epub 2017 Jul 13.
Pharm Res. 2017.
PMID: 28707164
Free PMC article.
Review.
Item in Clipboard
A mechanistic model to account for the Donnan and volume exclusion effects in ultrafiltration/diafiltration process of protein formulations.
Yu Z, Moomaw JF, Thyagarajapuram NR, Geng SB, Bent CJ, Tang Y.
Yu Z, et al. Among authors: thyagarajapuram nr.
Biotechnol Prog. 2021 Mar;37(2):e3106. doi: 10.1002/btpr.3106. Epub 2020 Dec 14.
Biotechnol Prog. 2021.
PMID: 33289341
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The structure, stability, and complex behavior of recombinant human gelatins.
Thyagarajapuram N, Olsen D, Middaugh CR.
Thyagarajapuram N, et al.
J Pharm Sci. 2007 Dec;96(12):3363-78. doi: 10.1002/jps.21022.
J Pharm Sci. 2007.
PMID: 17518362
Item in Clipboard
Probing protein structure and dynamics by second-derivative ultraviolet absorption analysis of cation-{pi} interactions.
Lucas LH, Ersoy BA, Kueltzo LA, Joshi SB, Brandau DT, Thyagarajapuram N, Peek LJ, Middaugh CR.
Lucas LH, et al.
Protein Sci. 2006 Oct;15(10):2228-43. doi: 10.1110/ps.062133706. Epub 2006 Sep 8.
Protein Sci. 2006.
PMID: 16963649
Free PMC article.
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Stabilization of proteins by recombinant human gelatins.
Thyagarajapuram N, Olsen D, Middaugh CR.
Thyagarajapuram N, et al.
J Pharm Sci. 2007 Dec;96(12):3304-15. doi: 10.1002/jps.20980.
J Pharm Sci. 2007.
PMID: 17542020
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Clinical Investigation of Large Volume Subcutaneous Delivery up to 25 mL for Lean and Non-Lean Subjects.
Dang X, Shih H, Sharma R, Angwin-Kaerner DT, Lin K, Kapur S, Thyagarajapuram NR, Shi GH, Collins DS.
Dang X, et al. Among authors: thyagarajapuram nr.
Pharm Res. 2024 Apr;41(4):751-763. doi: 10.1007/s11095-024-03683-5. Epub 2024 Mar 5.
Pharm Res. 2024.
PMID: 38443633
Clinical Trial.
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