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Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell RA. Gagliani N, et al. Among authors: iseppon a. Nature. 2015 Jul 9;523(7559):221-5. doi: 10.1038/nature14452. Epub 2015 Apr 29. Nature. 2015. PMID: 25924064 Free PMC article.
Feedback control of AHR signalling regulates intestinal immunity.
Schiering C, Wincent E, Metidji A, Iseppon A, Li Y, Potocnik AJ, Omenetti S, Henderson CJ, Wolf CR, Nebert DW, Stockinger B. Schiering C, et al. Among authors: iseppon a. Nature. 2017 Feb 9;542(7640):242-245. doi: 10.1038/nature21080. Epub 2017 Feb 1. Nature. 2017. PMID: 28146477 Free PMC article.
Intestinal IFN-γ-producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease.
Alfen JS, Larghi P, Facciotti F, Gagliani N, Bosotti R, Paroni M, Maglie S, Gruarin P, Vasco CM, Ranzani V, Frusteri C, Iseppon A, Moro M, Crosti MC, Gatti S, Pagani M, Caprioli F, Abrignani S, Flavell RA, Geginat J. Alfen JS, et al. Among authors: iseppon a. J Allergy Clin Immunol. 2018 Nov;142(5):1537-1547.e8. doi: 10.1016/j.jaci.2017.12.984. Epub 2018 Jan 31. J Allergy Clin Immunol. 2018. PMID: 29369775 Free article.
IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus.
Facciotti F, Gagliani N, Häringer B, Alfen JS, Penatti A, Maglie S, Paroni M, Iseppon A, Moro M, Crosti MC, Stölzel K, Romagnani C, Moroni G, Ingegnoli F, Torretta S, Pignataro L, Annoni A, Russo F, Pagani M, Abrignani S, Meroni P, Flavell R, Geginat J. Facciotti F, et al. Among authors: iseppon a. J Allergy Clin Immunol. 2016 Jan;137(1):318-321.e5. doi: 10.1016/j.jaci.2015.06.044. Epub 2015 Aug 25. J Allergy Clin Immunol. 2016. PMID: 26318071 No abstract available.
Vitamin D regulates microbiome-dependent cancer immunity.
Giampazolias E, Pereira da Costa M, Lam KC, Lim KHJ, Cardoso A, Piot C, Chakravarty P, Blasche S, Patel S, Biram A, Castro-Dopico T, Buck MD, Rodrigues RR, Poulsen GJ, Palma-Duran SA, Rogers NC, Koufaki MA, Minutti CM, Wang P, Vdovin A, Frederico B, Childs E, Lee S, Simpson B, Iseppon A, Omenetti S, Kelly G, Goldstone R, Nye E, Suárez-Bonnet A, Priestnall SL, MacRae JI, Zelenay S, Patil KR, Litchfield K, Lee JC, Jess T, Goldszmid RS, Reis E Sousa C. Giampazolias E, et al. Among authors: iseppon a. Science. 2024 Apr 26;384(6694):428-437. doi: 10.1126/science.adh7954. Epub 2024 Apr 25. Science. 2024. PMID: 38662827 Free PMC article.