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Disrupting a key hydrophobic pair in the oligomerization interface of the actinoporins impairs their pore-forming activity.
Mesa-Galloso H, Delgado-Magnero KH, Cabezas S, López-Castilla A, Hernández-González JE, Pedrera L, Alvarez C, Peter Tieleman D, García-Sáez AJ, Lanio ME, Ros U, Valiente PA. Mesa-Galloso H, et al. Among authors: cabezas s. Protein Sci. 2017 Mar;26(3):550-565. doi: 10.1002/pro.3104. Epub 2017 Feb 23. Protein Sci. 2017. PMID: 28000294 Free PMC article.
Sticholysin II shows similar immunostimulatory properties to LLO stimulating dendritic cells and MHC-I restricted T cell responses of heterologous antigen.
Del Valle A, Acosta-Rivero N, Laborde RJ, Cruz-Leal Y, Cabezas S, Luzardo MC, Alvarez C, Labrada M, Rodríguez A, Rodríguez GL, Raymond J, Nogueira CV, Grubaugh D, Fernández LE, Higgins D, Lanio ME. Del Valle A, et al. Among authors: cabezas s. Toxicon. 2021 Sep;200:38-47. doi: 10.1016/j.toxicon.2021.06.020. Epub 2021 Jul 6. Toxicon. 2021. PMID: 34237340
31 results