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Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.
Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM. Trapasso F, et al. Among authors: croce cm. J Biol Chem. 2017 Aug 25;292(34):14279. doi: 10.1074/jbc.A117.709062. J Biol Chem. 2017. PMID: 28842474 Free PMC article. No abstract available.
FHIT in human cancer.
Sozzi G, Huebner K, Croce CM. Sozzi G, et al. Among authors: croce cm. Adv Cancer Res. 1998;74:141-66. doi: 10.1016/s0065-230x(08)60766-6. Adv Cancer Res. 1998. PMID: 9561268 Review. No abstract available.
Role of FHIT in human cancer.
Croce CM, Sozzi G, Huebner K. Croce CM, et al. J Clin Oncol. 1999 May;17(5):1618-24. doi: 10.1200/JCO.1999.17.5.1618. J Clin Oncol. 1999. PMID: 10334551
Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.
Trapasso F, Krakowiak A, Cesari R, Arkles J, Yendamuri S, Ishii H, Vecchione A, Kuroki T, Bieganowski P, Pace HC, Huebner K, Croce CM, Brenner C. Trapasso F, et al. Among authors: croce cm. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1592-7. doi: 10.1073/pnas.0437915100. Epub 2003 Feb 6. Proc Natl Acad Sci U S A. 2003. PMID: 12574506 Free PMC article.
Cancer and the FRA3B/FHIT fragile locus: it's a HIT.
Huebner K, Croce CM. Huebner K, et al. Among authors: croce cm. Br J Cancer. 2003 May 19;88(10):1501-6. doi: 10.1038/sj.bjc.6600937. Br J Cancer. 2003. PMID: 12771912 Free PMC article.
Regression of upper gastric cancer in mice by FHIT gene delivery.
Ishii H, Zanesi N, Vecchione A, Trapasso F, Yendamuri S, Sarti M, Baffa R, During MJ, Huebner K, Fong LY, Croce CM. Ishii H, et al. Among authors: croce cm. FASEB J. 2003 Sep;17(12):1768-70. doi: 10.1096/fj.03-0241fje. Epub 2003 Jul 3. FASEB J. 2003. PMID: 12958204
Fhit is a physiological target of the protein kinase Src.
Pekarsky Y, Garrison PN, Palamarchuk A, Zanesi N, Aqeilan RI, Huebner K, Barnes LD, Croce CM. Pekarsky Y, et al. Among authors: croce cm. Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3775-9. doi: 10.1073/pnas.0400481101. Epub 2004 Mar 8. Proc Natl Acad Sci U S A. 2004. PMID: 15007172 Free PMC article.
1,233 results