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The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study.
Hagens MHJ, Golla SSV, Janssen B, Vugts DJ, Beaino W, Windhorst AD, O'Brien-Brown J, Kassiou M, Schuit RC, Schwarte LA, de Vries HE, Killestein J, Barkhof F, van Berckel BNM, Lammertsma AA. Hagens MHJ, et al. Among authors: o brien brown j. Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):379-389. doi: 10.1007/s00259-019-04550-x. Epub 2019 Nov 8. Eur J Nucl Med Mol Imaging. 2020. PMID: 31705174 Free PMC article.
The novel P2X7 receptor antagonist PKT100 improves cardiac function and survival in pulmonary hypertension by direct targeting of the right ventricle.
Hansen T, Karimi Galougahi K, Besnier M, Genetzakis E, Tsang M, Finemore M, O'Brien-Brown J, Di Bartolo BA, Kassiou M, Bubb KJ, Figtree GA. Hansen T, et al. Among authors: o brien brown j. Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H183-H191. doi: 10.1152/ajpheart.00580.2019. Epub 2020 May 29. Am J Physiol Heart Circ Physiol. 2020. PMID: 32469637 Free article.
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs.
Beinat C, Reekie T, Banister SD, O'Brien-Brown J, Xie T, Olson TT, Xiao Y, Harvey A, O'Connor S, Coles C, Grishin A, Kolesik P, Tsanaktsidis J, Kassiou M. Beinat C, et al. Among authors: o brien brown j. Eur J Med Chem. 2015 May 5;95:277-301. doi: 10.1016/j.ejmech.2015.03.025. Epub 2015 Mar 14. Eur J Med Chem. 2015. PMID: 25827398
Novel plasma protein binding analysis method for a PET tracer and its radiometabolites: A case study with [11C]SMW139 to explain the high uptake of radiometabolites in mouse brain.
Aarnio R, Alzghool OM, Wahlroos S, O'Brien-Brown J, Kassiou M, Solin O, Rinne JO, Forsback S, Haaparanta-Solin M. Aarnio R, et al. Among authors: o brien brown j. J Pharm Biomed Anal. 2022 Sep 20;219:114860. doi: 10.1016/j.jpba.2022.114860. Epub 2022 May 28. J Pharm Biomed Anal. 2022. PMID: 35738120 Free article.