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Page 1
Synthesis and Activity of a New Series of Antileishmanial Agents.
Kanwar A, Eduful BJ, Barbeto L, Carletti Bonomo P, Lemus A, Vesely BA, Mutka TS, Azhari A, Kyle DE, Leahy JW. Kanwar A, et al. Among authors: leahy jw. ACS Med Chem Lett. 2017 Jul 31;8(8):797-801. doi: 10.1021/acsmedchemlett.7b00039. eCollection 2017 Aug 10. ACS Med Chem Lett. 2017. PMID: 28835791 Free PMC article.
Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine.
Dempsey DR, Nichols DA, Battistini MR, Pemberton O, Ospina SR, Zhang X, Carpenter AM, O'Flynn BG, Leahy JW, Kanwar A, Lewandowski EM, Chen Y, Merkler DJ. Dempsey DR, et al. Among authors: leahy jw. Sci Rep. 2017 Oct 18;7(1):13432. doi: 10.1038/s41598-017-13669-6. Sci Rep. 2017. PMID: 29044148 Free PMC article.
Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD.
Sabbagh JJ, Cordova RA, Zheng D, Criado-Marrero M, Lemus A, Li P, Baker JD, Nordhues BA, Darling AL, Martinez-Licha C, Rutz DA, Patel S, Buchner J, Leahy JW, Koren J 3rd, Dickey CA, Blair LJ. Sabbagh JJ, et al. Among authors: leahy jw. ACS Chem Biol. 2018 Aug 17;13(8):2288-2299. doi: 10.1021/acschembio.8b00454. Epub 2018 Jun 19. ACS Chem Biol. 2018. PMID: 29893552 Free PMC article.
Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp.
Botnar A, Lawrence G, Maher SP, Vantaux A, Witkowski B, Shiau JC, Merino EF, De Vore D, Yang C, Murray C, Cassera MB, Leahy JW, Kyle DE. Botnar A, et al. Among authors: leahy jw. Int J Parasitol. 2022 Oct;52(11):733-744. doi: 10.1016/j.ijpara.2022.03.003. Epub 2022 Apr 18. Int J Parasitol. 2022. PMID: 35447149 Free PMC article.
Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation.
Hill SE, Beaulieu-Abdelahad D, Lemus A, Webster JM, Ospina SR, Darling AL, Martin MD, Patel S, Bridenstine L, Swonger R, Paul S, Blackburn R, Calcul L, Dickey CA, Leahy JW, Blair LJ. Hill SE, et al. Among authors: leahy jw. ACS Chem Biol. 2023 May 19;18(5):1124-1135. doi: 10.1021/acschembio.2c00919. Epub 2023 May 5. ACS Chem Biol. 2023. PMID: 37144894 Free PMC article.
Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases.
Kassu M, Parvatkar PT, Milanes J, Monaghan NP, Kim C, Dowgiallo M, Zhao Y, Asakawa AH, Huang L, Wagner A, Miller B, Carter K, Barrett KF, Tillery LM, Barrett LK, Phan IQ, Subramanian S, Myler PJ, Van Voorhis WC, Leahy JW, Rice CA, Kyle DE, Morris J, Manetsch R. Kassu M, et al. Among authors: leahy jw. ACS Infect Dis. 2023 Nov 10;9(11):2190-2201. doi: 10.1021/acsinfecdis.3c00284. Epub 2023 Oct 11. ACS Infect Dis. 2023. PMID: 37820055 Free PMC article.
Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome.
Mansfield CR, Quan B, Chirgwin ME, Eduful B, Hughes PF, Neveu G, Sylvester K, Ryan DH, Kafsack BFC, Haystead TAJ, Leahy JW, Fitzgerald MC, Derbyshire ER. Mansfield CR, et al. Among authors: leahy jw. Cell Chem Biol. 2024 Apr 18;31(4):729-742.e13. doi: 10.1016/j.chembiol.2024.02.008. Epub 2024 Mar 15. Cell Chem Biol. 2024. PMID: 38492573
Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists.
Ibrahim MA, Johnson HW, Jeong JW, Lewis GL, Shi X, Noguchi RT, Williams M, Leahy JW, Nuss JM, Woolfrey J, Banica M, Bentzien F, Chou YC, Gibson A, Heald N, Lamb P, Mattheakis L, Matthews D, Shipway A, Wu X, Zhang W, Zhou S, Shankar G. Ibrahim MA, et al. Among authors: leahy jw. J Med Chem. 2012 Feb 9;55(3):1368-81. doi: 10.1021/jm201533b. Epub 2012 Jan 24. J Med Chem. 2012. PMID: 22214363
Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors.
Leahy JW, Buhr CA, Johnson HW, Kim BG, Baik T, Cannoy J, Forsyth TP, Jeong JW, Lee MS, Ma S, Noson K, Wang L, Williams M, Nuss JM, Brooks E, Foster P, Goon L, Heald N, Holst C, Jaeger C, Lam S, Lougheed J, Nguyen L, Plonowski A, Song J, Stout T, Wu X, Yakes MF, Yu P, Zhang W, Lamb P, Raeber O. Leahy JW, et al. J Med Chem. 2012 Jun 14;55(11):5467-82. doi: 10.1021/jm300403a. Epub 2012 May 17. J Med Chem. 2012. PMID: 22548342
23 results