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The effects of β-D-mannuronic acid (M2000), as a novel NSAID, on COX1 and COX2 activities and gene expression in ankylosing spondylitis patients and the murine monocyte/macrophage, J774 cell line.
Jafarnezhad-Ansariha F, Yekaninejad MS, Jamshidi AR, Mansouri R, Vojdanian M, Mahmoudi M, Fattahi MJ, Hashemi SN, Rehm BHA, Matsuo H, Esposito E, Cuzzocrea S, Mirshafiey A. Jafarnezhad-Ansariha F, et al. Among authors: rehm bha. Inflammopharmacology. 2018 Apr;26(2):375-384. doi: 10.1007/s10787-017-0386-4. Epub 2017 Aug 17. Inflammopharmacology. 2018. PMID: 28819782 Clinical Trial.
M2000: a revolution in pharmacology.
Mirshafiey A, Cuzzocrea S, Rehm BH, Matsuo H. Mirshafiey A, et al. Med Sci Monit. 2005 Aug;11(8):PI53-63. Epub 2005 Jul 25. Med Sci Monit. 2005. PMID: 16049391
The Potent Inhibitory Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property on Anti-Cyclic Citrullinated Peptide Antibodies, Rheumatoid Factor and Anti-dsDNA Antibodies in Patients with Rheumatoid Arthritis.
Ahmadi H, Jamshidi AR, Mahmoudi M, Cuzzocrea S, Fattahi MJ, Barati A, Rehm BHA, Matsuo H, Mirshafiey A. Ahmadi H, et al. Among authors: rehm bha. Curr Drug Discov Technol. 2017;14(3):206-214. doi: 10.2174/1570163814666170321113059. Curr Drug Discov Technol. 2017. PMID: 28325148 Clinical Trial.
Evaluation of the efficacy and safety of β-d-mannuronic acid in patients with ankylosing spondylitis: A 12-week randomized, placebo-controlled, phase I/II clinical trial.
Fattahi MJ, Jamshidi AR, Mahmoudi M, Vojdanian M, Yekaninejad MS, Jafarnezhad-Ansariha F, Ahmadi H, Rehm BHA, Matsuo H, Cuzzocrea S, Hosseini M, Hashemi SN, Aghazadeh Z, Mirshafiey A. Fattahi MJ, et al. Among authors: rehm bha. Int Immunopharmacol. 2018 Jan;54:112-117. doi: 10.1016/j.intimp.2017.11.003. Epub 2017 Nov 8. Int Immunopharmacol. 2018. PMID: 29127910 Clinical Trial.
A phase I/II randomized, controlled, clinical trial for assessment of the efficacy and safety of β-D-mannuronic acid in rheumatoid arthritis patients.
Ahmadi H, Jamshidi AR, Gharibdoost F, Mahmoudi M, Rastkari N, Mostafaei S, Fattahi MJ, Vojdanian M, Cuzzocrea S, Rehm BHA, Matsuo H, Hosseini M, Aghazadeh Z, Mortazavi-Jahromi SS, Mirshafiey A. Ahmadi H, et al. Among authors: rehm bha. Inflammopharmacology. 2018 Jun;26(3):737-745. doi: 10.1007/s10787-018-0475-z. Epub 2018 Apr 25. Inflammopharmacology. 2018. PMID: 29696564 Clinical Trial.
International multicenter randomized, placebo-controlled phase III clinical trial of β-D-mannuronic acid in rheumatoid arthritis patients.
Rezaieyazdi Z, Farooqi A, Soleymani-Salehabadi H, Ahmadzadeh A, Aslani M, Omidian S, Sadoughi A, Vahidi Z, Khodashahi M, Zamurrad S, Mortazavi-Jahromi SS, Fallahzadeh H, Hosseini M, Aghazadeh Z, Ekhtiari P, Matsuo H, Rehm BHA, Cuzzocrea S, D'Aniello A, Mirshafiey A. Rezaieyazdi Z, et al. Among authors: rehm bha. Inflammopharmacology. 2019 Oct;27(5):911-921. doi: 10.1007/s10787-018-00557-2. Epub 2019 Jan 2. Inflammopharmacology. 2019. PMID: 30604197 Clinical Trial.
A randomized, controlled, phase II clinical trial of β-D-mannuronic acid (M2000) in pre-surgical breast cancer patients at early stage (T1-T2).
Kashefi S, Omranipour R, Mahmoodzadeh H, Ahmadi H, Alikhassi A, Hosseini M, Cuzzocrea S, Rehm BHA, Matsuo H, Mirshafiey A. Kashefi S, et al. Among authors: rehm bha. Clin Exp Pharmacol Physiol. 2019 Jun;46(6):527-532. doi: 10.1111/1440-1681.13086. Clin Exp Pharmacol Physiol. 2019. PMID: 30887570 Clinical Trial.
189 results