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Pyridine-pyrimidine amides that prevent HGF-induced epithelial scattering by two distinct mechanisms.
Bioorg Med Chem Lett. 2017 Sep 1;27(17):3992-4000. doi: 10.1016/j.bmcl.2017.07.063. Epub 2017 Jul 25.
Bioorg Med Chem Lett. 2017.
PMID: 28780159
Cellular contractility changes are sufficient to drive epithelial scattering.
Hoj JP, Davis JA, Fullmer KE, Morrell DJ, Saguibo NE, Schuler JT, Tuttle KJ, Hansen MD.
Hoj JP, et al. Among authors: schuler jt.
Exp Cell Res. 2014 Aug 15;326(2):187-200. doi: 10.1016/j.yexcr.2014.04.011. Epub 2014 Apr 26.
Exp Cell Res. 2014.
PMID: 24780819
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A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions.
Gregory Call S, Brereton D, Bullard JT, Chung JY, Meacham KL, Morrell DJ, Reeder DJ, Schuler JT, Slade AD, Hansen MD.
Gregory Call S, et al. Among authors: schuler jt.
Biochem Biophys Res Commun. 2011 Nov 25;415(3):485-9. doi: 10.1016/j.bbrc.2011.10.099. Epub 2011 Oct 28.
Biochem Biophys Res Commun. 2011.
PMID: 22056563
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