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VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart.
Kivelä R, Bry M, Robciuc MR, Räsänen M, Taavitsainen M, Silvola JM, Saraste A, Hulmi JJ, Anisimov A, Mäyränpää MI, Lindeman JH, Eklund L, Hellberg S, Hlushchuk R, Zhuang ZW, Simons M, Djonov V, Knuuti J, Mervaala E, Alitalo K. Kivelä R, et al. EMBO Mol Med. 2014 Mar;6(3):307-21. doi: 10.1002/emmm.201303147. Epub 2014 Jan 21. EMBO Mol Med. 2014. PMID: 24448490 Free PMC article.
Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling.
Mäntyselkä S, Kolari K, Baumert P, Ylä-Outinen L, Kuikka L, Lahtonen S, Permi P, Wackerhage H, Kalenius E, Kivelä R, Hulmi JJ. Mäntyselkä S, et al. Among authors: kivela r. Am J Physiol Endocrinol Metab. 2024 Jan 1;326(1):E73-E91. doi: 10.1152/ajpendo.00151.2023. Epub 2023 Nov 22. Am J Physiol Endocrinol Metab. 2024. PMID: 37991454
64 results