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'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase.
Carvalho I, Andrade P, Campo VL, Guedes PM, Sesti-Costa R, Silva JS, Schenkman S, Dedola S, Hill L, Rejzek M, Nepogodiev SA, Field RA. Carvalho I, et al. Bioorg Med Chem. 2010 Apr 1;18(7):2412-27. doi: 10.1016/j.bmc.2010.02.053. Epub 2010 Mar 2. Bioorg Med Chem. 2010. PMID: 20335038 Free article.
CuAAC click chemistry with N-propargyl 1,5-dideoxy-1,5-imino-D-gulitol and N-propargyl 1,6-dideoxy-1,6-imino-D-mannitol provides access to triazole-linked piperidine and azepane pseudo-disaccharide iminosugars displaying glycosidase inhibitory properties.
Zamoner LO, Aragão-Leoneti V, Mantoani SP, Rugen MD, Nepogodiev SA, Field RA, Carvalho I. Zamoner LO, et al. Among authors: carvalho i. Carbohydr Res. 2016 Jun 24;429:29-37. doi: 10.1016/j.carres.2016.04.020. Epub 2016 Apr 22. Carbohydr Res. 2016. PMID: 27160849
591 results