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Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.
Roversi P, Marti L, Caputo AT, Alonzi DS, Hill JC, Dent KC, Kumar A, Levasseur MD, Lia A, Waksman T, Basu S, Soto Albrecht Y, Qian K, McIvor JP, Lipp CB, Siliqi D, Vasiljević S, Mohammed S, Lukacik P, Walsh MA, Santino A, Zitzmann N. Roversi P, et al. Among authors: kumar a. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8544-8549. doi: 10.1073/pnas.1703682114. Epub 2017 Jul 24. Proc Natl Acad Sci U S A. 2017. PMID: 28739903 Free PMC article.
Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose: Glycoprotein glucosyltransferase.
Modenutti CP, Blanco Capurro JI, Ibba R, Alonzi DS, Song MN, Vasiljević S, Kumar A, Chandran AV, Tax G, Marti L, Hill JC, Lia A, Hensen M, Waksman T, Rushton J, Rubichi S, Santino A, Martí MA, Zitzmann N, Roversi P. Modenutti CP, et al. Among authors: kumar a. Structure. 2021 Apr 1;29(4):357-370.e9. doi: 10.1016/j.str.2020.11.017. Epub 2020 Dec 21. Structure. 2021. PMID: 33352114 Free PMC article.
Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein.
Behrens AJ, Vasiljevic S, Pritchard LK, Harvey DJ, Andev RS, Krumm SA, Struwe WB, Cupo A, Kumar A, Zitzmann N, Seabright GE, Kramer HB, Spencer DI, Royle L, Lee JH, Klasse PJ, Burton DR, Wilson IA, Ward AB, Sanders RW, Moore JP, Doores KJ, Crispin M. Behrens AJ, et al. Among authors: kumar a. Cell Rep. 2016 Mar 22;14(11):2695-706. doi: 10.1016/j.celrep.2016.02.058. Epub 2016 Mar 10. Cell Rep. 2016. PMID: 26972002 Free PMC article.
Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages.
Behrens AJ, Kumar A, Medina-Ramirez M, Cupo A, Marshall K, Cruz Portillo VM, Harvey DJ, Ozorowski G, Zitzmann N, Wilson IA, Ward AB, Struwe WB, Moore JP, Sanders RW, Crispin M. Behrens AJ, et al. Among authors: kumar a. J Proteome Res. 2018 Mar 2;17(3):987-999. doi: 10.1021/acs.jproteome.7b00639. Epub 2018 Feb 8. J Proteome Res. 2018. PMID: 29420040 Free PMC article.
The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication.
Zhuang X, Magri A, Hill M, Lai AG, Kumar A, Rambhatla SB, Donald CL, Lopez-Clavijo AF, Rudge S, Pinnick K, Chang WH, Wing PAC, Brown R, Qin X, Simmonds P, Baumert TF, Ray D, Loudon A, Balfe P, Wakelam M, Butterworth S, Kohl A, Jopling CL, Zitzmann N, McKeating JA. Zhuang X, et al. Among authors: kumar a. Nat Commun. 2019 Jan 22;10(1):377. doi: 10.1038/s41467-019-08299-7. Nat Commun. 2019. PMID: 30670689 Free PMC article.
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