Adenosine A2A receptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis.
Mediero A, Wilder T, Shah L, Cronstein BN.
Mediero A, et al.
FASEB J. 2018 Jul;32(7):3487-3501. doi: 10.1096/fj.201700217R. Epub 2018 Feb 2.
FASEB J. 2018.
PMID: 29394106
Free PMC article.
CGS21680 decreased RANKL, increased OPG, and increased total/nuclear beta-catenin expression in osteoblasts. Sema4D increased Ras homolog gene family, member A phosphorylation and focal adhesion kinase activation in osteoclast precursors, and CGS21680 abrogated these effec …
CGS21680 decreased RANKL, increased OPG, and increased total/nuclear beta-catenin expression in osteoblasts. Sema4D increased Ras homolog ge …