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Feedback between p21 and reactive oxygen production is necessary for cell senescence.
Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T. Passos JF, et al. Among authors: nelson g. Mol Syst Biol. 2010;6:347. doi: 10.1038/msb.2010.5. Epub 2010 Feb 16. Mol Syst Biol. 2010. PMID: 20160708 Free PMC article.
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.
Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T. Jurk D, et al. Among authors: nelson g. Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172. Nat Commun. 2014. PMID: 24960204 Free PMC article.
Mitochondria are required for pro-ageing features of the senescent phenotype.
Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. Correia-Melo C, et al. Among authors: nelson g. EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4. EMBO J. 2016. PMID: 26848154 Free PMC article.
The bystander effect contributes to the accumulation of senescent cells in vivo.
da Silva PFL, Ogrodnik M, Kucheryavenko O, Glibert J, Miwa S, Cameron K, Ishaq A, Saretzki G, Nagaraja-Grellscheid S, Nelson G, von Zglinicki T. da Silva PFL, et al. Among authors: nelson g. Aging Cell. 2019 Feb;18(1):e12848. doi: 10.1111/acel.12848. Epub 2018 Nov 21. Aging Cell. 2019. PMID: 30462359 Free PMC article.
Bioengineering the microanatomy of human skin.
Roger M, Fullard N, Costello L, Bradbury S, Markiewicz E, O'Reilly S, Darling N, Ritchie P, Määttä A, Karakesisoglou I, Nelson G, von Zglinicki T, Dicolandrea T, Isfort R, Bascom C, Przyborski S. Roger M, et al. Among authors: nelson g. J Anat. 2019 Apr;234(4):438-455. doi: 10.1111/joa.12942. Epub 2019 Feb 10. J Anat. 2019. PMID: 30740672 Free PMC article.
The mTORC1-autophagy pathway is a target for senescent cell elimination.
Kucheryavenko O, Nelson G, von Zglinicki T, Korolchuk VI, Carroll B. Kucheryavenko O, et al. Among authors: nelson g. Biogerontology. 2019 Jun;20(3):331-335. doi: 10.1007/s10522-019-09802-9. Epub 2019 Feb 23. Biogerontology. 2019. PMID: 30798505 Free PMC article.
1,859 results