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Stabilization of protein-protein interactions in drug discovery.
Andrei SA, Sijbesma E, Hann M, Davis J, O'Mahony G, Perry MWD, Karawajczyk A, Eickhoff J, Brunsveld L, Doveston RG, Milroy LG, Ottmann C. Andrei SA, et al. Among authors: eickhoff j. Expert Opin Drug Discov. 2017 Sep;12(9):925-940. doi: 10.1080/17460441.2017.1346608. Epub 2017 Jul 11. Expert Opin Drug Discov. 2017. PMID: 28695752 Review.
Modulators of 14-3-3 Protein-Protein Interactions.
Stevers LM, Sijbesma E, Botta M, MacKintosh C, Obsil T, Landrieu I, Cau Y, Wilson AJ, Karawajczyk A, Eickhoff J, Davis J, Hann M, O'Mahony G, Doveston RG, Brunsveld L, Ottmann C. Stevers LM, et al. Among authors: eickhoff j. J Med Chem. 2018 May 10;61(9):3755-3778. doi: 10.1021/acs.jmedchem.7b00574. Epub 2017 Oct 19. J Med Chem. 2018. PMID: 28968506 Free PMC article. Review.
IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Andlovic B, Heilmann G, Ninck S, Andrei SA, Centorrino F, Higuchi Y, Kato N, Brunsveld L, Arkin M, Menninger S, Choidas A, Wolf A, Klebl B, Kaschani F, Kaiser M, Eickhoff J, Ottmann C. Andlovic B, et al. Among authors: eickhoff j. Cell Chem Biol. 2023 Jun 15;30(6):573-590.e6. doi: 10.1016/j.chembiol.2023.04.005. Epub 2023 May 1. Cell Chem Biol. 2023. PMID: 37130519
Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß.
Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi HT, Nihongaki Y, Flegel J, Mejdrová I, Eickhoff J, Baumann M, Nencka R, Janning P, Kordes S, Schöler HR, Sterneckert J, Inoue T, Ziegler S, Waldmann H. Kremer L, et al. Among authors: eickhoff j. Angew Chem Int Ed Engl. 2019 Nov 11;58(46):16617-16628. doi: 10.1002/anie.201907632. Epub 2019 Oct 4. Angew Chem Int Ed Engl. 2019. PMID: 31454140 Free PMC article. Review.
Kinase Chemodiversity from the Arctic: The Breitfussins.
Hansen KØ, Andersen JH, Bayer A, Pandey SK, Lorentzen M, Jørgensen KB, Sydnes MO, Guttormsen Y, Baumann M, Koch U, Klebl B, Eickhoff J, Haug BE, Isaksson J, Hansen EH. Hansen KØ, et al. Among authors: eickhoff j. J Med Chem. 2019 Nov 27;62(22):10167-10181. doi: 10.1021/acs.jmedchem.9b01006. Epub 2019 Nov 14. J Med Chem. 2019. PMID: 31647655
The role of RIP2 in p38 MAPK activation in the stressed heart.
Jacquet S, Nishino Y, Kumphune S, Sicard P, Clark JE, Kobayashi KS, Flavell RA, Eickhoff J, Cotten M, Marber MS. Jacquet S, et al. Among authors: eickhoff j. J Biol Chem. 2008 May 2;283(18):11964-71. doi: 10.1074/jbc.M707750200. Epub 2008 Feb 29. J Biol Chem. 2008. PMID: 18310079 Free PMC article.
A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations.
Hutterer C, Eickhoff J, Milbradt J, Korn K, Zeitträger I, Bahsi H, Wagner S, Zischinsky G, Wolf A, Degenhart C, Unger A, Baumann M, Klebl B, Marschall M. Hutterer C, et al. Among authors: eickhoff j. Antimicrob Agents Chemother. 2015 Apr;59(4):2062-71. doi: 10.1128/AAC.04534-14. Epub 2015 Jan 26. Antimicrob Agents Chemother. 2015. PMID: 25624324 Free PMC article.
Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo.
Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler HCA, Menninger S, Zischinsky G, Eickhoff J, Fröb C, Bhattarai P, Arulmozhivarman G, Marrone L, Janosch A, Adachi K, Stehling M, Anderson EN, Abo-Rady M, Bickle M, Pandey UB, Reimer MM, Kizil C, Schöler HR, Nussbaumer P, Klebl B, Sterneckert JL. Reinhardt L, et al. Among authors: eickhoff j. Stem Cell Reports. 2019 Mar 5;12(3):502-517. doi: 10.1016/j.stemcr.2019.01.015. Epub 2019 Feb 14. Stem Cell Reports. 2019. PMID: 30773488 Free PMC article.
438 results