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Stabilization of protein-protein interactions in drug discovery.
Andrei SA, Sijbesma E, Hann M, Davis J, O'Mahony G, Perry MWD, Karawajczyk A, Eickhoff J, Brunsveld L, Doveston RG, Milroy LG, Ottmann C. Andrei SA, et al. Among authors: doveston rg. Expert Opin Drug Discov. 2017 Sep;12(9):925-940. doi: 10.1080/17460441.2017.1346608. Epub 2017 Jul 11. Expert Opin Drug Discov. 2017. PMID: 28695752 Review.
Structural interface between LRRK2 and 14-3-3 protein.
Stevers LM, de Vries RM, Doveston RG, Milroy LG, Brunsveld L, Ottmann C. Stevers LM, et al. Among authors: doveston rg. Biochem J. 2017 Mar 23;474(7):1273-1287. doi: 10.1042/BCJ20161078. Biochem J. 2017. PMID: 28202711
Modulators of 14-3-3 Protein-Protein Interactions.
Stevers LM, Sijbesma E, Botta M, MacKintosh C, Obsil T, Landrieu I, Cau Y, Wilson AJ, Karawajczyk A, Eickhoff J, Davis J, Hann M, O'Mahony G, Doveston RG, Brunsveld L, Ottmann C. Stevers LM, et al. Among authors: doveston rg. J Med Chem. 2018 May 10;61(9):3755-3778. doi: 10.1021/acs.jmedchem.7b00574. Epub 2017 Oct 19. J Med Chem. 2018. PMID: 28968506 Free PMC article. Review.
Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
Guillory X, Wolter M, Leysen S, Neves JF, Kuusk A, Genet S, Somsen B, Morrow JK, Rivers E, van Beek L, Patel J, Goodnow R, Schoenherr H, Fuller N, Cao Q, Doveston RG, Brunsveld L, Arkin MR, Castaldi P, Boyd H, Landrieu I, Chen H, Ottmann C. Guillory X, et al. Among authors: doveston rg. J Med Chem. 2020 Jul 9;63(13):6694-6707. doi: 10.1021/acs.jmedchem.9b01942. Epub 2020 Jun 23. J Med Chem. 2020. PMID: 32501690 Free PMC article.
24 results