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Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.
Kristensen LH, Nielsen AL, Helgstrand C, Lees M, Cloos P, Kastrup JS, Helin K, Olsen L, Gajhede M. Kristensen LH, et al. Among authors: olsen l. FEBS J. 2012 Jun;279(11):1905-14. doi: 10.1111/j.1742-4658.2012.08567.x. Epub 2012 May 2. FEBS J. 2012. PMID: 22420752 Free article.
Identification of catechols as histone-lysine demethylase inhibitors.
Nielsen AL, Kristensen LH, Stephansen KB, Kristensen JB, Helgstrand C, Lees M, Cloos P, Helin K, Gajhede M, Olsen L. Nielsen AL, et al. Among authors: olsen l. FEBS Lett. 2012 Apr 24;586(8):1190-4. doi: 10.1016/j.febslet.2012.03.001. Epub 2012 Mar 15. FEBS Lett. 2012. PMID: 22575654 Free article.
Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylases.
Kristensen JB, Nielsen AL, Jørgensen L, Kristensen LH, Helgstrand C, Juknaite L, Kristensen JL, Kastrup JS, Clausen RP, Olsen L, Gajhede M. Kristensen JB, et al. Among authors: olsen l. FEBS Lett. 2011 Jun 23;585(12):1951-6. doi: 10.1016/j.febslet.2011.05.023. Epub 2011 May 12. FEBS Lett. 2011. PMID: 21575637 Free article.
1,028 results