Cystathionine γ-lyase deficiency aggravates obesity-related insulin resistance via FoxO1-dependent hepatic gluconeogenesis.
Guo W, Li D, You Y, Li W, Hu B, Zhang S, Miao L, Xian M, Zhu Y, Shen X.
Guo W, et al.
FASEB J. 2019 Mar;33(3):4212-4224. doi: 10.1096/fj.201801894R. Epub 2018 Dec 10.
FASEB J. 2019.
PMID: 30526049
Our study reveals a double-edged sword effect and a novel mechanism for CSE/H(2)S in obesity associated with insulin resistance and provides evidence for CSE/H(2)S as a promising therapeutic potential target for obesity-related insulin resistance.-Guo, W., Li, D., Y …
Our study reveals a double-edged sword effect and a novel mechanism for CSE/H(2)S in obesity associated with insulin resistance and provides …