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Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair.
López-Iglesias AA, Herrero AB, Chesi M, San-Segundo L, González-Méndez L, Hernández-García S, Misiewicz-Krzeminska I, Quwaider D, Martín-Sánchez M, Primo D, Paíno T, Bergsagel PL, Mehrling T, González-Díaz M, San-Miguel JF, Mateos MV, Gutiérrez NC, Garayoa M, Ocio EM. López-Iglesias AA, et al. J Hematol Oncol. 2017 Jun 20;10(1):127. doi: 10.1186/s13045-017-0495-y. J Hematol Oncol. 2017. PMID: 28633670 Free PMC article.
Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival.
Mateos MV, García-Sanz R, López-Pérez R, Moro MJ, Ocio E, Hernández J, Megido M, Caballero MD, Fernández-Calvo J, Bárez A, Almeida J, Orfão A, González M, San Miguel JF. Mateos MV, et al. Br J Haematol. 2002 Sep;118(4):1034-40. doi: 10.1046/j.1365-2141.2002.03749.x. Br J Haematol. 2002. PMID: 12199782 Free article.
Bortezomib is an efficient agent in plasma cell leukemias.
Esparís-Ogando A, Alegre A, Aguado B, Mateo G, Gutiérrez N, Bladé J, Schenkein D, Pandiella A, San Miguel JF. Esparís-Ogando A, et al. Int J Cancer. 2005 Apr 20;114(4):665-7. doi: 10.1002/ijc.20793. Int J Cancer. 2005. PMID: 15609327 Free article.
Multifunctional role of Erk5 in multiple myeloma.
Carvajal-Vergara X, Tabera S, Montero JC, Esparís-Ogando A, López-Pérez R, Mateo G, Gutiérrez N, Parmo-Cabañas M, Teixidó J, San Miguel JF, Pandiella A. Carvajal-Vergara X, et al. Blood. 2005 Jun 1;105(11):4492-9. doi: 10.1182/blood-2004-08-2985. Epub 2005 Feb 3. Blood. 2005. PMID: 15692064 Free article.
Cell cycle analysis of Waldenstrom's macroglobulinemia.
Ocio EM, Mateo G, Vidriales B, Lopez-Berges MC, Garcia-Sanz R, Hernandez JM, Orfao A, San Miguel JF. Ocio EM, et al. Clin Lymphoma. 2005 Mar;5(4):250-2. doi: 10.3816/clm.2005.n.009. Clin Lymphoma. 2005. PMID: 15794858
662 results