Gotti C - Search Results

1

Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation.

Simoni E, Bartolini M, Abu IF, Blockley A, Gotti C, Bottegoni G, Caporaso R, Bergamini C, Andrisano V, Cavalli A, Mellor IR, Minarini A, Rosini M. Simoni E, et al. Among authors: gotti c. Future Med Chem. 2017 Jun;9(10):953-963. doi: 10.4155/fmc-2017-0039. Epub 2017 Jun 20. Future Med Chem. 2017. PMID: 28632446

2

Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes.

Tasso B, Canu Boido C, Terranova E, Gotti C, Riganti L, Clementi F, Artali R, Bombieri G, Meneghetti F, Sparatore F. Tasso B, et al. Among authors: gotti c. J Med Chem. 2009 Jul 23;52(14):4345-57. doi: 10.1021/jm900225j. J Med Chem. 2009. PMID: 19548687

3

Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed as α4β2-Nicotinic Acetylcholine Receptor Agonists.

Bolchi C, Valoti E, Gotti C, Fasoli F, Ruggeri P, Fumagalli L, Binda M, Mucchietto V, Sciaccaluga M, Budriesi R, Fucile S, Pallavicini M. Bolchi C, et al. Among authors: gotti c. J Med Chem. 2015 Aug 27;58(16):6665-77. doi: 10.1021/acs.jmedchem.5b00904. Epub 2015 Aug 18. J Med Chem. 2015. PMID: 26225816 Free article.

4

Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.

Rizzi L, Dallanoce C, Matera C, Magrone P, Pucci L, Gotti C, Clementi F, De Amici M. Rizzi L, et al. Among authors: gotti c. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4651-4. doi: 10.1016/j.bmcl.2008.07.016. Epub 2008 Jul 10. Bioorg Med Chem Lett. 2008. PMID: 18644719 Free article.

5

Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.

Dallanoce C, Magrone P, Matera C, Lo Presti L, De Amici M, Riganti L, Clementi F, Gotti C, De Micheli C. Dallanoce C, et al. Among authors: gotti c. Eur J Med Chem. 2010 Dec;45(12):5594-601. doi: 10.1016/j.ejmech.2010.09.009. Epub 2010 Sep 17. Eur J Med Chem. 2010. PMID: 20932609

6

Unichiral 2-(2'-pyrrolidinyl)-1,4-benzodioxanes: the 2R,2'S diastereomer of the N-methyl-7-hydroxy analogue is a potent α4β2- and α6β2-nicotinic acetylcholine receptor partial agonist.

Bolchi C, Gotti C, Binda M, Fumagalli L, Pucci L, Pistillo F, Vistoli G, Valoti E, Pallavicini M. Bolchi C, et al. Among authors: gotti c. J Med Chem. 2011 Nov 10;54(21):7588-601. doi: 10.1021/jm200937t. Epub 2011 Oct 11. J Med Chem. 2011. PMID: 21942635

7

Design, synthesis and binding affinity of acetylcholine carbamoyl analogues.

Bolchi C, Valoti E, Binda M, Fasoli F, Ferrara R, Fumagalli L, Gotti C, Matucci R, Vistoli G, Pallavicini M. Bolchi C, et al. Among authors: gotti c. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6481-5. doi: 10.1016/j.bmcl.2013.09.023. Epub 2013 Sep 18. Bioorg Med Chem Lett. 2013. PMID: 24128660

8

Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization.

Matera C, Pucci L, Fiorentini C, Fucile S, Missale C, Grazioso G, Clementi F, Zoli M, De Amici M, Gotti C, Dallanoce C. Matera C, et al. Among authors: gotti c. Eur J Med Chem. 2015 Aug 28;101:367-83. doi: 10.1016/j.ejmech.2015.06.039. Epub 2015 Jun 20. Eur J Med Chem. 2015. PMID: 26164842

9

Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities for α4β2 neuronal nicotinic acetylcholine receptors.

Deligia F, Deiana V, Gotti C, Lazzari P, Bottazzi ME, Pucci L, Fasoli F, Ragusa G, Pinna GA, Murineddu G. Deligia F, et al. Among authors: gotti c. Eur J Med Chem. 2015 Oct 20;103:429-37. doi: 10.1016/j.ejmech.2015.09.006. Epub 2015 Sep 9. Eur J Med Chem. 2015. PMID: 26383127

10

Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype.

Matera C, Quadri M, Sciaccaluga M, Pomè DY, Fasoli F, De Amici M, Fucile S, Gotti C, Dallanoce C, Grazioso G. Matera C, et al. Among authors: gotti c. Eur J Med Chem. 2016 Jan 27;108:392-405. doi: 10.1016/j.ejmech.2015.11.045. Epub 2015 Dec 5. Eur J Med Chem. 2016. PMID: 26706350 Free article.

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