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A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.
Hill R, Kalathur RK, Callejas S, Colaço L, Brandão R, Serelde B, Cebriá A, Blanco-Aparicio C, Pastor J, Futschik M, Dopazo A, Link W. Hill R, et al. Among authors: link w. Breast Cancer Res. 2014 Dec 9;16(6):482. doi: 10.1186/s13058-014-0482-y. Breast Cancer Res. 2014. PMID: 25488803 Free PMC article.
Introduction to FOXO Biology.
Link W. Link W. Methods Mol Biol. 2019;1890:1-9. doi: 10.1007/978-1-4939-8900-3_1. Methods Mol Biol. 2019. PMID: 30414140 Review.
FOXO transcription factors as therapeutic targets in human diseases.
Orea-Soufi A, Paik J, Bragança J, Donlon TA, Willcox BJ, Link W. Orea-Soufi A, et al. Among authors: link w. Trends Pharmacol Sci. 2022 Dec;43(12):1070-1084. doi: 10.1016/j.tips.2022.09.010. Epub 2022 Oct 21. Trends Pharmacol Sci. 2022. PMID: 36280450 Review.
166 results