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Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.
Parthier C, Kleinschmidt M, Neumann P, Rudolph R, Manhart S, Schlenzig D, Fanghänel J, Rahfeld JU, Demuth HU, Stubbs MT. Parthier C, et al. Among authors: kleinschmidt m. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13942-7. doi: 10.1073/pnas.0706404104. Epub 2007 Aug 21. Proc Natl Acad Sci U S A. 2007. PMID: 17715056 Free PMC article.
Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate.
Asztalos P, Parthier C, Golbik R, Kleinschmidt M, Hübner G, Weiss MS, Friedemann R, Wille G, Tittmann K. Asztalos P, et al. Among authors: kleinschmidt m. Biochemistry. 2007 Oct 30;46(43):12037-52. doi: 10.1021/bi700844m. Epub 2007 Oct 3. Biochemistry. 2007. PMID: 17914867
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU. Cynis H, et al. Among authors: kleinschmidt m. EMBO Mol Med. 2011 Sep;3(9):545-58. doi: 10.1002/emmm.201100158. Epub 2011 Jul 20. EMBO Mol Med. 2011. PMID: 21774078 Free PMC article.
Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.
Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. Frost JL, et al. Among authors: kleinschmidt m. Am J Pathol. 2013 Aug;183(2):369-81. doi: 10.1016/j.ajpath.2013.05.005. Epub 2013 Jun 7. Am J Pathol. 2013. PMID: 23747948 Free PMC article.
Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease.
Hartlage-Rübsamen M, Waniek A, Meissner J, Morawski M, Schilling S, Jäger C, Kleinschmidt M, Cynis H, Kehlen A, Arendt T, Demuth HU, Rossner S. Hartlage-Rübsamen M, et al. Among authors: kleinschmidt m. Acta Neuropathol. 2015 Apr;129(4):565-83. doi: 10.1007/s00401-015-1395-2. Epub 2015 Feb 11. Acta Neuropathol. 2015. PMID: 25666182 Free PMC article.
112 results