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Cry6Aa1, a Bacillus thuringiensis nematocidal and insecticidal toxin, forms pores in planar lipid bilayers at extremely low concentrations and without the need of proteolytic processing.
Fortea E, Lemieux V, Potvin L, Chikwana V, Griffin S, Hey T, McCaskill D, Narva K, Tan SY, Xu X, Vachon V, Schwartz JL. Fortea E, et al. J Biol Chem. 2017 Aug 11;292(32):13122-13132. doi: 10.1074/jbc.M116.765941. Epub 2017 Jun 16. J Biol Chem. 2017. PMID: 28623231 Free PMC article.
TMEM16 scramblases thin the membrane to enable lipid scrambling.
Falzone ME, Feng Z, Alvarenga OE, Pan Y, Lee B, Cheng X, Fortea E, Scheuring S, Accardi A. Falzone ME, et al. Among authors: fortea e. Nat Commun. 2022 May 11;13(1):2604. doi: 10.1038/s41467-022-30300-z. Nat Commun. 2022. PMID: 35562175 Free PMC article.
Structural basis of pH-dependent activation in a CLC transporter.
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HD, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A. Fortea E, et al. Nat Struct Mol Biol. 2024 Apr;31(4):644-656. doi: 10.1038/s41594-023-01210-5. Epub 2024 Jan 26. Nat Struct Mol Biol. 2024. PMID: 38279055
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