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The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers.
Harrill AH, Roach J, Fier I, Eaddy JS, Kurtz CL, Antoine DJ, Spencer DM, Kishimoto TK, Pisetsky DS, Park BK, Watkins PB. Harrill AH, et al. Among authors: watkins pb. Clin Pharmacol Ther. 2012 Aug;92(2):214-20. doi: 10.1038/clpt.2012.40. Epub 2012 Jun 27. Clin Pharmacol Ther. 2012. PMID: 22739141 Free PMC article. Clinical Trial.
In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.
Howell BA, Yang Y, Kumar R, Woodhead JL, Harrill AH, Clewell HJ 3rd, Andersen ME, Siler SQ, Watkins PB. Howell BA, et al. Among authors: watkins pb. J Pharmacokinet Pharmacodyn. 2012 Oct;39(5):527-41. doi: 10.1007/s10928-012-9266-0. Epub 2012 Aug 9. J Pharmacokinet Pharmacodyn. 2012. PMID: 22875368
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
Bhattacharya S, Shoda LK, Zhang Q, Woods CG, Howell BA, Siler SQ, Woodhead JL, Yang Y, McMullen P, Watkins PB, Andersen ME. Bhattacharya S, et al. Among authors: watkins pb. Front Physiol. 2012 Dec 14;3:462. doi: 10.3389/fphys.2012.00462. eCollection 2012. Front Physiol. 2012. PMID: 23248599 Free PMC article.
Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid-Mediated DILI.
Woodhead JL, Yang K, Brouwer KL, Siler SQ, Stahl SH, Ambroso JL, Baker D, Watkins PB, Howell BA. Woodhead JL, et al. Among authors: watkins pb. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 9;3(7):e123. doi: 10.1038/psp.2014.21. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25006780 Free PMC article.
269 results