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Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety--fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis.
Rydzik AM, Kulis M, Lukaszewicz M, Kowalska J, Zuberek J, Darzynkiewicz ZM, Darzynkiewicz E, Jemielity J. Rydzik AM, et al. Among authors: darzynkiewicz e, darzynkiewicz zm. Bioorg Med Chem. 2012 Mar 1;20(5):1699-710. doi: 10.1016/j.bmc.2012.01.013. Epub 2012 Jan 20. Bioorg Med Chem. 2012. PMID: 22316555
Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential.
Strenkowska M, Grzela R, Majewski M, Wnek K, Kowalska J, Lukaszewicz M, Zuberek J, Darzynkiewicz E, Kuhn AN, Sahin U, Jemielity J. Strenkowska M, et al. Among authors: darzynkiewicz e. Nucleic Acids Res. 2016 Nov 16;44(20):9578-9590. doi: 10.1093/nar/gkw896. Epub 2016 Oct 7. Nucleic Acids Res. 2016. PMID: 27903882 Free PMC article.
mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation.
Rydzik AM, Warminski M, Sikorski PJ, Baranowski MR, Walczak S, Kowalska J, Zuberek J, Lukaszewicz M, Nowak E, W Claridge TD, Darzynkiewicz E, Nowotny M, Jemielity J. Rydzik AM, et al. Among authors: darzynkiewicz e. Nucleic Acids Res. 2017 Sep 6;45(15):8661-8675. doi: 10.1093/nar/gkx569. Nucleic Acids Res. 2017. PMID: 28666355 Free PMC article.
The first examples of mRNA cap analogs bearing boranophosphate modification.
Kowalska J, Zuberek J, Darzynkiewicz ZM, Lukaszewicz M, Darzynkiewicz E, Jemielity J. Kowalska J, et al. Among authors: darzynkiewicz e, darzynkiewicz zm. Nucleic Acids Symp Ser (Oxf). 2008;(52):289-90. doi: 10.1093/nass/nrn146. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776367
168 results