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Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.
Brouwers O, Niessen PM, Haenen G, Miyata T, Brownlee M, Stehouwer CD, De Mey JG, Schalkwijk CG. Brouwers O, et al. Among authors: schalkwijk cg. Diabetologia. 2010 May;53(5):989-1000. doi: 10.1007/s00125-010-1677-0. Epub 2010 Feb 26. Diabetologia. 2010. PMID: 20186387 Free PMC article.
Methylglyoxal and glyoxalase I in atherosclerosis.
Hanssen NM, Stehouwer CD, Schalkwijk CG. Hanssen NM, et al. Biochem Soc Trans. 2014 Apr;42(2):443-9. doi: 10.1042/BST20140001. Biochem Soc Trans. 2014. PMID: 24646258 Review.
Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.
Nokin MJ, Durieux F, Peixoto P, Chiavarina B, Peulen O, Blomme A, Turtoi A, Costanza B, Smargiasso N, Baiwir D, Scheijen JL, Schalkwijk CG, Leenders J, De Tullio P, Bianchi E, Thiry M, Uchida K, Spiegel DA, Cochrane JR, Hutton CA, De Pauw E, Delvenne P, Belpomme D, Castronovo V, Bellahcène A. Nokin MJ, et al. Elife. 2016 Oct 19;5:e19375. doi: 10.7554/eLife.19375. Elife. 2016. PMID: 27759563 Free PMC article.
Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer.
Nokin MJ, Bellier J, Durieux F, Peulen O, Rademaker G, Gabriel M, Monseur C, Charloteaux B, Verbeke L, van Laere S, Roncarati P, Herfs M, Lambert C, Scheijen J, Schalkwijk C, Colige A, Caers J, Delvenne P, Turtoi A, Castronovo V, Bellahcène A. Nokin MJ, et al. Among authors: schalkwijk c. Breast Cancer Res. 2019 Jan 23;21(1):11. doi: 10.1186/s13058-018-1095-7. Breast Cancer Res. 2019. PMID: 30674353 Free PMC article.
522 results