The deuterium isotope effect on the NMR signal of the low-barrier hydrogen bond in a transition-state analog complex of chymotrypsin.
Cassidy CS, Lin J, Frey PA.
Cassidy CS, et al. Among authors: lin j.
Biochem Biophys Res Commun. 2000 Jul 5;273(2):789-92. doi: 10.1006/bbrc.2000.2986.
Biochem Biophys Res Commun. 2000.
PMID: 10873682
The participation of a low-barrier hydrogen bond (LBHB) in the mechanism of action of chymotrypsin introduces a new role for Asp 102 and His 57 in catalysis [C. S. Cassidy, J. Lin, and P. A. Frey (1997) Biochemistry 36, 4576-4584]. It is postulated that the LBHB inc …
The participation of a low-barrier hydrogen bond (LBHB) in the mechanism of action of chymotrypsin introduces a new role for Asp 102 and His …