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Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition.
Mol Cell Endocrinol. 2017 Aug 15;451:1-14. doi: 10.1016/j.mce.2017.05.033. Epub 2017 May 30.
Mol Cell Endocrinol. 2017.
PMID: 28576744
Review.
Tumor cell resistance against targeted therapeutics: the density of cultured glioma tumor cells enhances Stat3 activity and offers protection against the tyrosine kinase inhibitor canertinib.
von Manstein V, Groner B.
von Manstein V, et al.
Medchemcomm. 2016 Oct 14;8(1):96-102. doi: 10.1039/c6md00463f. eCollection 2017 Jan 1.
Medchemcomm. 2016.
PMID: 30108694
Free PMC article.
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Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops.
von Manstein V, Yang CM, Richter D, Delis N, Vafaizadeh V, Groner B.
von Manstein V, et al.
Curr Signal Transduct Ther. 2013 Dec;8(3):193-202. doi: 10.2174/1574362409666140206221931.
Curr Signal Transduct Ther. 2013.
PMID: 25045345
Free PMC article.
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Expression of the miR-302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes.
Yang CM, Chiba T, Brill B, Delis N, von Manstein V, Vafaizadeh V, Oellerich T, Groner B.
Yang CM, et al. Among authors: von manstein v.
Int J Cancer. 2015 Nov 15;137(10):2296-309. doi: 10.1002/ijc.29606. Epub 2015 Jun 5.
Int J Cancer. 2015.
PMID: 25991553
Free PMC article.
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Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.
Khageh Hosseini S, Kolterer S, Steiner M, von Manstein V, Gerlach K, Trojan J, Waidmann O, Zeuzem S, Schulze JO, Hahn S, Steinhilber D, Gatterdam V, Tampé R, Biondi RM, Proschak E, Zörnig M.
Khageh Hosseini S, et al. Among authors: von manstein v.
Biochem Pharmacol. 2017 Dec 15;146:53-62. doi: 10.1016/j.bcp.2017.10.003. Epub 2017 Oct 13.
Biochem Pharmacol. 2017.
PMID: 29031818
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