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High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence.
Mohamed EA, Giama NH, Abdalla AO, Shaleh HM, Oseini AM, Ali HA, Ahmed F, Taha W, Ahmed Mohammed H, Cvinar J, Waaeys IA, Ali H, Allotey LK, Ali AO, Mohamed SA, Harmsen WS, Ahmmad EM, Bajwa NA, Afgarshe MD, Shire AM, Balls-Berry JE, Roberts LR. Mohamed EA, et al. Among authors: shire am. World J Gastroenterol. 2022 Sep 21;28(35):5217-5229. doi: 10.3748/wjg.v28.i35.5217. World J Gastroenterol. 2022. PMID: 36188718 Free PMC article.
Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease.
Kim TH, Banini BA, Asumda FZ, Campbell NA, Hu C, Moser CD, Shire AM, Han S, Ma C, Krishnan A, Mounajjed T, White TA, Gores GJ, LeBrasseur NK, Charlton MR, Roberts LR. Kim TH, et al. Among authors: shire am. Am J Physiol Gastrointest Liver Physiol. 2020 Sep 1;319(3):G333-G344. doi: 10.1152/ajpgi.00150.2019. Epub 2020 Jul 20. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 32683952 Free PMC article.
The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism.
Zheng X, Vittar NB, Gai X, Fernandez-Barrena MG, Moser CD, Hu C, Almada LL, McCleary-Wheeler AL, Elsawa SF, Vrabel AM, Shire AM, Comba A, Thorgeirsson SS, Kim Y, Liu Q, Fernandez-Zapico ME, Roberts LR. Zheng X, et al. Among authors: shire am. PLoS One. 2012;7(11):e49581. doi: 10.1371/journal.pone.0049581. Epub 2012 Nov 19. PLoS One. 2012. PMID: 23185371 Free PMC article.
The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling.
Zheng X, Gai X, Han S, Moser CD, Hu C, Shire AM, Floyd RA, Roberts LR. Zheng X, et al. Among authors: shire am. Genes Chromosomes Cancer. 2013 Mar;52(3):225-36. doi: 10.1002/gcc.22022. Epub 2012 Oct 29. Genes Chromosomes Cancer. 2013. PMID: 23109092 Free PMC article.
23 results