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Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site.
Commun Biol. 2023 Jun 24;6(1):670. doi: 10.1038/s42003-023-05039-y.
Commun Biol. 2023.
PMID: 37355752
Free PMC article.
Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
Schmidt FC, Fitz K, Feilen LP, Okochi M, Steiner H, Langosch D.
Schmidt FC, et al. Among authors: feilen lp.
J Biol Chem. 2023 May;299(5):104626. doi: 10.1016/j.jbc.2023.104626. Epub 2023 Mar 20.
J Biol Chem. 2023.
PMID: 36944398
Free PMC article.
Item in Clipboard
Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
Feilen LP, Chen SY, Fukumori A, Feederle R, Zacharias M, Steiner H.
Feilen LP, et al.
Elife. 2022 May 17;11:e76090. doi: 10.7554/eLife.76090.
Elife. 2022.
PMID: 35579427
Free PMC article.
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Substrate recruitment by γ-secretase.
Fukumori A, Feilen LP, Steiner H.
Fukumori A, et al. Among authors: feilen lp.
Semin Cell Dev Biol. 2020 Sep;105:54-63. doi: 10.1016/j.semcdb.2020.03.006. Epub 2020 Apr 22.
Semin Cell Dev Biol. 2020.
PMID: 32331992
Review.
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Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction.
Feilen LP, Haubrich K, Strecker P, Probst S, Eggert S, Stier G, Sinning I, Konietzko U, Kins S, Simon B, Wild K.
Feilen LP, et al.
Front Mol Neurosci. 2017 May 11;10:140. doi: 10.3389/fnmol.2017.00140. eCollection 2017.
Front Mol Neurosci. 2017.
PMID: 28553201
Free PMC article.
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