Hamel E - Search Results

1

3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.

La Regina G, Bai R, Coluccia A, Famiglini V, Passacantilli S, Naccarato V, Ortar G, Mazzoccoli C, Ruggieri V, Agriesti F, Piccoli C, Tataranni T, Nalli M, Brancale A, Vultaggio S, Mercurio C, Varasi M, Saponaro C, Sergio S, Maffia M, Coluccia AML, Hamel E, Silvestri R. La Regina G, et al. Among authors: hamel e. ACS Med Chem Lett. 2017 Apr 26;8(5):521-526. doi: 10.1021/acsmedchemlett.7b00022. eCollection 2017 May 11. ACS Med Chem Lett. 2017. PMID: 28523104 Free PMC article.

2

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.

Getahun Z, Jurd L, Chu PS, Lin CM, Hamel E. Getahun Z, et al. Among authors: hamel e. J Med Chem. 1992 Mar 20;35(6):1058-67. doi: 10.1021/jm00084a011. J Med Chem. 1992. PMID: 1552500

3

Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.

Bai R, Friedman SJ, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Biochem Pharmacol. 1992 Jun 23;43(12):2637-45. doi: 10.1016/0006-2952(92)90153-a. Biochem Pharmacol. 1992. PMID: 1632820

4

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. J Biol Chem. 1991 Aug 25;266(24):15882-9. J Biol Chem. 1991. PMID: 1874739 Free article.

5

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

Bai RL, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. J Biol Chem. 1990 Oct 5;265(28):17141-9. J Biol Chem. 1990. PMID: 2211617 Free article.

6

Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.

Bai RL, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. Biochem Pharmacol. 1990 Oct 15;40(8):1859-64. doi: 10.1016/0006-2952(90)90367-t. Biochem Pharmacol. 1990. PMID: 2242019

7

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.

Bai R, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Biochem Pharmacol. 1990 Jun 15;39(12):1941-9. doi: 10.1016/0006-2952(90)90613-p. Biochem Pharmacol. 1990. PMID: 2353935

8

Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.

Bai RL, Lin CM, Nguyen NY, Liu TY, Hamel E. Bai RL, et al. Among authors: hamel e. Biochemistry. 1989 Jun 27;28(13):5606-12. doi: 10.1021/bi00439a040. Biochemistry. 1989. PMID: 2775724

Shown in previous studies to inhibit tubulin polymerization [Abraham, I., Dion, R. L., Duanmu, C., Gottesman, M. M., & Hamel, E. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 6839-6843] and to form a covalent bond preferentially with beta-tubulin [Bai, R., Duanmu, C. …

Shown in previous studies to inhibit tubulin polymerization [Abraham, I., Dion, R. L., Duanmu, C., Gottesman, M. M., & Hamel, …

9

Mechanism of action of the antimitotic drug 2,4-dichlorobenzyl thiocyanate: alkylation of sulfhydryl group(s) of beta-tubulin.

Bai R, Duanmu C, Hamel E. Bai R, et al. Among authors: hamel e. Biochim Biophys Acta. 1989 Jan 19;994(1):12-20. doi: 10.1016/0167-4838(89)90056-3. Biochim Biophys Acta. 1989. PMID: 2909252

The compound, 2,4-dichlorobenzyl thiocyanate (DCBT) was previously shown to cause mitotic arrest, disruption of intracellular microtubules, and inhibition of tubulin polymerization, with resistance to the drug conferred by a mutation in a beta-tubulin gene (Abraham, I., Dion, R.L …

The compound, 2,4-dichlorobenzyl thiocyanate (DCBT) was previously shown to cause mitotic arrest, disruption of intracellular microtubules, …

10

The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.

Bai R, Taylor GF, Cichacz ZA, Herald CL, Kepler JA, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Biochemistry. 1995 Aug 1;34(30):9714-21. doi: 10.1021/bi00030a009. Biochemistry. 1995. PMID: 7626642

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