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Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Tech K, Tikunov AP, Farooq H, Morrissy AS, Meidinger J, Fish T, Green SC, Liu H, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJM, Marra MA, Vander Heiden MG, Taylor MD, Macdonald JM, Gershon TR. Tech K, et al. Among authors: vander heiden mg. Cancer Res. 2017 Jun 15;77(12):3217-3230. doi: 10.1158/0008-5472.CAN-16-3304. Epub 2017 May 17. Cancer Res. 2017. PMID: 28515149 Free PMC article.
Metabolic pathway alterations that support cell proliferation.
Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW. Vander Heiden MG, et al. Cold Spring Harb Symp Quant Biol. 2011;76:325-34. doi: 10.1101/sqb.2012.76.010900. Epub 2012 Jan 19. Cold Spring Harb Symp Quant Biol. 2011. PMID: 22262476 Review.
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.
Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G. Fendt SM, et al. Among authors: vander heiden mg. Cancer Res. 2013 Jul 15;73(14):4429-38. doi: 10.1158/0008-5472.CAN-13-0080. Epub 2013 May 17. Cancer Res. 2013. PMID: 23687346 Free PMC article.
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG. Israelsen WJ, et al. Among authors: vander heiden mg. Cell. 2013 Oct 10;155(2):397-409. doi: 10.1016/j.cell.2013.09.025. Cell. 2013. PMID: 24120138 Free PMC article.
Pyruvate kinase: Function, regulation and role in cancer.
Israelsen WJ, Vander Heiden MG. Israelsen WJ, et al. Among authors: vander heiden mg. Semin Cell Dev Biol. 2015 Jul;43:43-51. doi: 10.1016/j.semcdb.2015.08.004. Epub 2015 Aug 13. Semin Cell Dev Biol. 2015. PMID: 26277545 Free PMC article. Review.
The Role of Pyruvate Kinase M2 in Cancer Metabolism.
Liu VM, Vander Heiden MG. Liu VM, et al. Among authors: vander heiden mg. Brain Pathol. 2015 Nov;25(6):781-3. doi: 10.1111/bpa.12311. Brain Pathol. 2015. PMID: 26526946 Free PMC article. Review.
Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance.
Dalin S, Sullivan MR, Lau AN, Grauman-Boss B, Mueller HS, Kreidl E, Fenoglio S, Luengo A, Lees JA, Vander Heiden MG, Lauffenburger DA, Hemann MT. Dalin S, et al. Among authors: vander heiden mg. Cancer Res. 2019 Nov 15;79(22):5723-5733. doi: 10.1158/0008-5472.CAN-19-0960. Epub 2019 Sep 4. Cancer Res. 2019. PMID: 31484670 Free PMC article.
239 results