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Tau association with synaptic vesicles causes presynaptic dysfunction.
Zhou L, McInnes J, Wierda K, Holt M, Herrmann AG, Jackson RJ, Wang YC, Swerts J, Beyens J, Miskiewicz K, Vilain S, Dewachter I, Moechars D, De Strooper B, Spires-Jones TL, De Wit J, Verstreken P. Zhou L, et al. Among authors: dewachter i. Nat Commun. 2017 May 11;8:15295. doi: 10.1038/ncomms15295. Nat Commun. 2017. PMID: 28492240 Free PMC article.
Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease.
De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. De Strooper B, et al. Among authors: dewachter i. J Biol Chem. 1995 Feb 24;270(8):4058-65. doi: 10.1074/jbc.270.8.4058. J Biol Chem. 1995. PMID: 7876155 Free article.
Modelling Alzheimer's disease in multiple transgenic mice.
Dewachter I, Moechars D, van Dorpe J, Tesseur I, Van den Haute C, Spittaels K, Van Leuven F. Dewachter I, et al. Biochem Soc Symp. 2001;(67):203-10. doi: 10.1042/bss0670203. Biochem Soc Symp. 2001. PMID: 11447836
We have reported transgenic mice with neuronal overexpression of the clinical mutant beta-amyloid precursor protein (APP) known as London, which develop an AD-related phenotype [Moechers, Dewachter, Lorent, Reverse, Baekelandt, Nadiu, Tesseur, Spittaels, Van den Haute, Che …
We have reported transgenic mice with neuronal overexpression of the clinical mutant beta-amyloid precursor protein (APP) known as London, w …
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice.
Peeraer E, Bottelbergs A, Van Kolen K, Stancu IC, Vasconcelos B, Mahieu M, Duytschaever H, Ver Donck L, Torremans A, Sluydts E, Van Acker N, Kemp JA, Mercken M, Brunden KR, Trojanowski JQ, Dewachter I, Lee VM, Moechars D. Peeraer E, et al. Among authors: dewachter i. Neurobiol Dis. 2015 Jan;73:83-95. doi: 10.1016/j.nbd.2014.08.032. Epub 2014 Sep 16. Neurobiol Dis. 2015. PMID: 25220759 Free PMC article.
80 results