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MTH1 as a Chemotherapeutic Target: The Elephant in the Room.
Samaranayake GJ, Huynh M, Rai P. Samaranayake GJ, et al. Among authors: rai p. Cancers (Basel). 2017 May 8;9(5):47. doi: 10.3390/cancers9050047. Cancers (Basel). 2017. PMID: 28481306 Free PMC article. Review.
The Existence of MTH1-independent 8-oxodGTPase Activity in Cancer Cells as a Compensatory Mechanism against On-target Effects of MTH1 Inhibitors.
Samaranayake GJ, Troccoli CI, Zhang L, Huynh M, Jayaraj CJ, Ji D, McPherson L, Onishi Y, Nguyen DM, Robbins DJ, Karbaschi M, Cooke MS, Barrientos A, Kool ET, Rai P. Samaranayake GJ, et al. Among authors: rai p. Mol Cancer Ther. 2020 Feb;19(2):432-446. doi: 10.1158/1535-7163.MCT-19-0437. Epub 2019 Nov 19. Mol Cancer Ther. 2020. PMID: 31744893 Free PMC article.
MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways.
Patel A, Burton DG, Halvorsen K, Balkan W, Reiner T, Perez-Stable C, Cohen A, Munoz A, Giribaldi MG, Singh S, Robbins DJ, Nguyen DM, Rai P. Patel A, et al. Among authors: rai p. Oncogene. 2015 May 14;34(20):2586-96. doi: 10.1038/onc.2014.195. Epub 2014 Jul 14. Oncogene. 2015. PMID: 25023700 Free PMC article.
MTH1 counteracts oncogenic oxidative stress.
Burton DG, Rai P. Burton DG, et al. Among authors: rai p. Oncoscience. 2015 Sep 12;2(10):785-6. doi: 10.18632/oncoscience.240. eCollection 2015. Oncoscience. 2015. PMID: 26682244 Free PMC article. No abstract available.
1,029 results