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The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta.
Gioia R, Tonelli F, Ceppi I, Biggiogera M, Leikin S, Fisher S, Tenedini E, Yorgan TA, Schinke T, Tian K, Schwartz JM, Forte F, Wagener R, Villani S, Rossi A, Forlino A. Gioia R, et al. Among authors: leikin s. Hum Mol Genet. 2017 Aug 1;26(15):2897-2911. doi: 10.1093/hmg/ddx171. Hum Mol Genet. 2017. PMID: 28475764 Free PMC article.
In utero transplantation of adult bone marrow decreases perinatal lethality and rescues the bone phenotype in the knockin murine model for classical, dominant osteogenesis imperfecta.
Panaroni C, Gioia R, Lupi A, Besio R, Goldstein SA, Kreider J, Leikin S, Vera JC, Mertz EL, Perilli E, Baruffaldi F, Villa I, Farina A, Casasco M, Cetta G, Rossi A, Frattini A, Marini JC, Vezzoni P, Forlino A. Panaroni C, et al. Among authors: leikin s. Blood. 2009 Jul 9;114(2):459-68. doi: 10.1182/blood-2008-12-195859. Epub 2009 May 4. Blood. 2009. PMID: 19414862 Free PMC article.
Chaperoning osteogenesis: new protein-folding disease paradigms.
Makareeva E, Aviles NA, Leikin S. Makareeva E, et al. Among authors: leikin s. Trends Cell Biol. 2011 Mar;21(3):168-76. doi: 10.1016/j.tcb.2010.11.007. Epub 2010 Dec 21. Trends Cell Biol. 2011. PMID: 21183349 Free PMC article. Review.
COL1 C-propeptide cleavage site mutations cause high bone mass osteogenesis imperfecta.
Lindahl K, Barnes AM, Fratzl-Zelman N, Whyte MP, Hefferan TE, Makareeva E, Brusel M, Yaszemski MJ, Rubin CJ, Kindmark A, Roschger P, Klaushofer K, McAlister WH, Mumm S, Leikin S, Kessler E, Boskey AL, Ljunggren O, Marini JC. Lindahl K, et al. Among authors: leikin s. Hum Mutat. 2011 Jun;32(6):598-609. doi: 10.1002/humu.21475. Epub 2011 Apr 7. Hum Mutat. 2011. PMID: 21344539 Free PMC article.
235 results