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Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury.
Peptides. 2017 Jun;92:38-45. doi: 10.1016/j.peptides.2017.04.005. Epub 2017 Apr 29.
Peptides. 2017.
PMID: 28465077
Long-lasting ameliorating effects of the oligodeoxynucleotide IMT504 on mechanical allodynia and hindpaw edema in rats with chronic hindpaw inflammation.
Leiguarda C, Coronel MF, Montaner AD, Villar MJ, Brumovsky PR.
Leiguarda C, et al.
Neurosci Lett. 2018 Feb 14;666:17-23. doi: 10.1016/j.neulet.2017.12.032. Epub 2017 Dec 14.
Neurosci Lett. 2018.
PMID: 29248616
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Intrathecal Administration of an Anti-nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization.
Leiguarda C, Villarreal A, Potilinski C, Pelissier T, Coronel MF, Bayo J, Ramos AJ, Montaner A, Villar MJ, Constandil L, Brumovsky PR.
Leiguarda C, et al.
J Neuroimmune Pharmacol. 2021 Dec;16(4):818-834. doi: 10.1007/s11481-021-09983-6. Epub 2021 Jan 27.
J Neuroimmune Pharmacol. 2021.
PMID: 33502706
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Transcript Expression of Vesicular Glutamate Transporters in Rat Dorsal Root Ganglion and Spinal Cord Neurons: Impact of Spinal Blockade during Hindpaw Inflammation.
Leiguarda C, McCarthy CJ, Casadei M, Lundgren KH, Coronel MF, Trigosso-Venario H, Seal RP, Seroogy KB, Brumovsky PR.
Leiguarda C, et al.
ACS Chem Neurosci. 2020 Sep 2;11(17):2602-2614. doi: 10.1021/acschemneuro.0c00272. Epub 2020 Aug 10.
ACS Chem Neurosci. 2020.
PMID: 32697906
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IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model.
Leiguarda C, Potilinski C, Rubione J, Tate P, Villar MJ, Montaner A, Bisagno V, Constandil L, Brumovsky PR.
Leiguarda C, et al.
J Neuroimmune Pharmacol. 2021 Sep;16(3):651-666. doi: 10.1007/s11481-020-09971-2. Epub 2020 Nov 21.
J Neuroimmune Pharmacol. 2021.
PMID: 33221983
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IMT504 blocks allodynia in rats with spared nerve injury by promoting the migration of mesenchymal stem cells and by favoring an anti-inflammatory milieu at the injured nerve.
Casadei M, Fiore E, Rubione J, Domínguez LM, Coronel MF, Leiguarda C, García M, Mazzolini G, Villar MJ, Montaner A, Constandil L, Romero-Sandoval EA, Brumovsky PR.
Casadei M, et al. Among authors: leiguarda c.
Pain. 2022 Jun 1;163(6):1114-1129. doi: 10.1097/j.pain.0000000000002476. Epub 2021 Sep 15.
Pain. 2022.
PMID: 34711765
Free PMC article.
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Modulation of the Inflammatory Response by Pre-emptive Administration of IMT504 Reduces Postoperative Pain in Rats and has Opioid-Sparing Effects.
Rubione J, Sbrascini SM, Miguel B, Leiguarda C, Coronel MF, McCarthy CJ, Montaner A, Villar MJ, Brumovsky PR.
Rubione J, et al. Among authors: leiguarda c.
J Pain. 2023 Jun;24(6):991-1008. doi: 10.1016/j.jpain.2023.01.013. Epub 2023 Jan 24.
J Pain. 2023.
PMID: 36706889
Free article.
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