Leung IKH - Search Results

1

Targeting isocitrate lyase for the treatment of latent tuberculosis.

Bhusal RP, Bashiri G, Kwai BXC, Sperry J, Leung IKH. Bhusal RP, et al. Among authors: leung ikh. Drug Discov Today. 2017 Jul;22(7):1008-1016. doi: 10.1016/j.drudis.2017.04.012. Epub 2017 Apr 27. Drug Discov Today. 2017. PMID: 28458043 Review.

2

Synthesis of the Azepinobisindole Alkaloid Iheyamine A Enabled by a Cross-Mannich Reaction.

Lindsay AC, Leung IKH, Sperry J. Lindsay AC, et al. Among authors: leung ikh. Org Lett. 2016 Oct 21;18(20):5404-5407. doi: 10.1021/acs.orglett.6b02798. Epub 2016 Oct 5. Org Lett. 2016. PMID: 27704854

3

MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance.

Son SJ, Huang R, Squire CJ, Leung IKH. Son SJ, et al. Among authors: leung ikh. Drug Discov Today. 2019 Jan;24(1):206-216. doi: 10.1016/j.drudis.2018.07.004. Epub 2018 Jul 20. Drug Discov Today. 2019. PMID: 30036574 Review.

4

Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors.

Bhusal RP, Patel K, Kwai BXC, Swartjes A, Bashiri G, Reynisson J, Sperry J, Leung IKH. Bhusal RP, et al. Among authors: leung ikh. Medchemcomm. 2017 Oct 17;8(11):2155-2163. doi: 10.1039/c7md00456g. eCollection 2017 Nov 1. Medchemcomm. 2017. PMID: 30108733 Free PMC article.

5

Targeting mRNA translation in Parkinson's disease.

Correddu D, Leung IKH. Correddu D, et al. Among authors: leung ikh. Drug Discov Today. 2019 Jun;24(6):1295-1303. doi: 10.1016/j.drudis.2019.04.003. Epub 2019 Apr 8. Drug Discov Today. 2019. PMID: 30974176 Review.

6

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.

Bhusal RP, Jiao W, Kwai BXC, Reynisson J, Collins AJ, Sperry J, Bashiri G, Leung IKH. Bhusal RP, et al. Among authors: leung ikh. Nat Commun. 2019 Oct 11;10(1):4639. doi: 10.1038/s41467-019-12614-7. Nat Commun. 2019. PMID: 31604954 Free PMC article.

7

Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase.

Kwai BXC, Collins AJ, Middleditch MJ, Sperry J, Bashiri G, Leung IKH. Kwai BXC, et al. Among authors: leung ikh. RSC Med Chem. 2020 Oct 19;12(1):57-61. doi: 10.1039/d0md00301h. eCollection 2021 Jan 1. RSC Med Chem. 2020. PMID: 34046597 Free PMC article.

8

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold.

Li-Zhulanov NS, Zakharenko AL, Chepanova AA, Patel J, Zafar A, Volcho KP, Salakhutdinov NF, Reynisson J, Leung IKH, Lavrik OI. Li-Zhulanov NS, et al. Among authors: leung ikh. Molecules. 2018 Sep 26;23(10):2468. doi: 10.3390/molecules23102468. Molecules. 2018. PMID: 30261631 Free PMC article.

9

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90).

Mak OW, Chand R, Reynisson J, Leung IKH. Mak OW, et al. Among authors: leung ikh. Int J Mol Sci. 2019 Oct 26;20(21):5333. doi: 10.3390/ijms20215333. Int J Mol Sci. 2019. PMID: 31717777 Free PMC article.

10

Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents.

Eurtivong C, Pilkington LI, van Rensburg M, White RM, Brar HK, Rees S, Paulin EK, Xu CS, Sharma N, Leung IKH, Leung E, Barker D, Reynisson J. Eurtivong C, et al. Among authors: leung ikh, leung e. Eur J Med Chem. 2020 Feb 1;187:111919. doi: 10.1016/j.ejmech.2019.111919. Epub 2019 Nov 27. Eur J Med Chem. 2020. PMID: 31810783

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