Macdonald IR - Search Results

1

Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer's Disease.

Macdonald IR, Maxwell SP, Reid GA, Cash MK, DeBay DR, Darvesh S. Macdonald IR, et al. J Alzheimers Dis. 2017;58(2):491-505. doi: 10.3233/JAD-170164. J Alzheimers Dis. 2017. PMID: 28453492 Free PMC article.

2

Butyrylcholinesterase activity in multiple sclerosis neuropathology.

Darvesh S, Leblanc AM, Macdonald IR, Reid GA, Bhan V, Macaulay RJ, Fisk JD. Darvesh S, et al. Among authors: macdonald ir. Chem Biol Interact. 2010 Sep 6;187(1-3):425-31. doi: 10.1016/j.cbi.2010.01.037. Epub 2010 Feb 1. Chem Biol Interact. 2010. PMID: 20122907

3

Synthesis and preliminary evaluation of piperidinyl and pyrrolidinyl iodobenzoates as imaging agents for butyrylcholinesterase.

Macdonald IR, Reid GA, Joy EE, Pottie IR, Matte G, Burrell S, Mawko G, Martin E, Darvesh S. Macdonald IR, et al. Mol Imaging Biol. 2011 Dec;13(6):1250-61. doi: 10.1007/s11307-010-0448-0. Mol Imaging Biol. 2011. PMID: 20976626

4

Thioesters for the in vitro evaluation of agents to image brain cholinesterases.

Macdonald IR, Jollymore CT, Reid GA, Pottie IR, Martin E, Darvesh S. Macdonald IR, et al. J Enzyme Inhib Med Chem. 2013 Jun;28(3):447-55. doi: 10.3109/14756366.2011.647008. Epub 2012 Jan 11. J Enzyme Inhib Med Chem. 2013. PMID: 22233541

5

Cysteine thioesters as myelin proteolipid protein analogues to examine the role of butyrylcholinesterase in myelin decompaction.

Pottie IR, Higgins EA, Blackman RA, Macdonald IR, Martin E, Darvesh S. Pottie IR, et al. Among authors: macdonald ir. ACS Chem Neurosci. 2011 Mar 16;2(3):151-9. doi: 10.1021/cn100090g. Epub 2010 Dec 30. ACS Chem Neurosci. 2011. PMID: 22778864 Free PMC article.

6

Probing the peripheral site of human butyrylcholinesterase.

Macdonald IR, Martin E, Rosenberry TL, Darvesh S. Macdonald IR, et al. Biochemistry. 2012 Sep 11;51(36):7046-53. doi: 10.1021/bi300955k. Epub 2012 Aug 27. Biochemistry. 2012. PMID: 22901043 Free PMC article.

7

Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems.

Darvesh S, Macdonald IR, Martin E. Darvesh S, et al. Among authors: macdonald ir. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3822-5. doi: 10.1016/j.bmcl.2013.04.082. Epub 2013 May 7. Bioorg Med Chem Lett. 2013. PMID: 23707254

8

Early detection of cerebral glucose uptake changes in the 5XFAD mouse.

Macdonald IR, DeBay DR, Reid GA, O'Leary TP, Jollymore CT, Mawko G, Burrell S, Martin E, Bowen CV, Brown RE, Darvesh S. Macdonald IR, et al. Curr Alzheimer Res. 2014;11(5):450-60. doi: 10.2174/1567205011666140505111354. Curr Alzheimer Res. 2014. PMID: 24801216 Free PMC article.

9

Cholinesterase inhibition in Alzheimer's disease: is specificity the answer?

Macdonald IR, Rockwood K, Martin E, Darvesh S. Macdonald IR, et al. J Alzheimers Dis. 2014;42(2):379-84. doi: 10.3233/JAD-140219. J Alzheimers Dis. 2014. PMID: 24898642 Review.

10

Synthesis and Preliminary Evaluation of Phenyl 4-123I-Iodophenylcarbamate for Visualization of Cholinesterases Associated with Alzheimer Disease Pathology.

Macdonald IR, Reid GA, Pottie IR, Martin E, Darvesh S. Macdonald IR, et al. J Nucl Med. 2016 Feb;57(2):297-302. doi: 10.2967/jnumed.115.162032. Epub 2015 Nov 5. J Nucl Med. 2016. PMID: 26541777 Free article.

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