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Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme.
Martinelli LKB, Rotta M, Villela AD, Rodrigues-Junior VS, Abbadi BL, Trindade RV, Petersen GO, Danesi GM, Nery LR, Pauli I, Campos MM, Bonan CD, de Souza ON, Basso LA, Santos DS. Martinelli LKB, et al. Among authors: villela ad. Sci Rep. 2017 Apr 24;7:46696. doi: 10.1038/srep46696. Sci Rep. 2017. PMID: 28436453 Free PMC article.
IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages.
Rodrigues-Junior VS, dos Santos Junior AA, Villela AD, Belardinelli JM, Morbidoni HR, Basso LA, Campos MM, Santos DS. Rodrigues-Junior VS, et al. Among authors: villela ad. Int J Antimicrob Agents. 2014 Jan;43(1):82-5. doi: 10.1016/j.ijantimicag.2013.08.021. Epub 2013 Oct 1. Int J Antimicrob Agents. 2014. PMID: 24139881
Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection.
Rodrigues-Junior VS, Villela AD, Gonçalves RS, Abbadi BL, Trindade RV, López-Gavín A, Tudó G, González-Martín J, Basso LA, de Souza MV, Campos MM, Santos DS. Rodrigues-Junior VS, et al. Among authors: villela ad. Int J Antimicrob Agents. 2016 Aug;48(2):203-7. doi: 10.1016/j.ijantimicag.2016.04.029. Epub 2016 Jun 7. Int J Antimicrob Agents. 2016. PMID: 27364701
New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis.
Giacobbo BC, Pissinate K, Rodrigues-Junior V, Villela AD, Grams ES, Abbadi BL, Subtil FT, Sperotto N, Trindade RV, Back DF, Campos MM, Basso LA, Machado P, Santos DS. Giacobbo BC, et al. Among authors: villela ad. Eur J Med Chem. 2017 Jan 27;126:491-501. doi: 10.1016/j.ejmech.2016.11.048. Epub 2016 Nov 23. Eur J Med Chem. 2017. PMID: 27914363
Activity of 2-(quinolin-4-yloxy)acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome sequencing.
Subtil FT, Villela AD, Abbadi BL, Rodrigues-Junior VS, Bizarro CV, Timmers LFSM, de Souza ON, Pissinate K, Machado P, López-Gavín A, Tudó G, González-Martín J, Basso LA, Santos DS. Subtil FT, et al. Among authors: villela ad. Int J Antimicrob Agents. 2018 Mar;51(3):378-384. doi: 10.1016/j.ijantimicag.2017.08.023. Epub 2017 Aug 23. Int J Antimicrob Agents. 2018. PMID: 28843821 Free article.
Characterisation of iunH gene knockout strain from Mycobacterium tuberculosis.
Villela AD, Rodrigues VD Junior, Pinto AF, Wink PL, Sánchez-Quitian ZA, Petersen GO, Campos MM, Basso LA, Santos DS. Villela AD, et al. Mem Inst Oswaldo Cruz. 2017 Mar;112(3):203-208. doi: 10.1590/0074-02760160462. Mem Inst Oswaldo Cruz. 2017. PMID: 28225907 Free PMC article.
26 results