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Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer.
Oncotarget. 2017 Mar 28;8(13):21806-21817. doi: 10.18632/oncotarget.15586.
Oncotarget. 2017.
PMID: 28423521
Free PMC article.
A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition.
Shee K, Wells JD, Ung M, Hampsch RA, Traphagen NA, Yang W, Liu SC, Zeldenrust MA, Wang L, Kalari KR, Yu J, Boughey JC, Demidenko E, Kettenbach AN, Cheng C, Goetz MP, Miller TW.
Shee K, et al. Among authors: hampsch ra.
Clin Cancer Res. 2020 Jan 1;26(1):159-170. doi: 10.1158/1078-0432.CCR-18-2213. Epub 2019 Sep 26.
Clin Cancer Res. 2020.
PMID: 31558472
Free PMC article.
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AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells.
Hampsch RA, Wells JD, Traphagen NA, McCleery CF, Fields JL, Shee K, Dillon LM, Pooler DB, Lewis LD, Demidenko E, Huang YH, Marotti JD, Goen AE, Kinlaw WB, Miller TW.
Hampsch RA, et al.
Clin Cancer Res. 2020 Jul 15;26(14):3707-3719. doi: 10.1158/1078-0432.CCR-20-0269. Epub 2020 Apr 22.
Clin Cancer Res. 2020.
PMID: 32321715
Free PMC article.
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Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
Shee K, Yang W, Hinds JW, Hampsch RA, Varn FS, Traphagen NA, Patel K, Cheng C, Jenkins NP, Kettenbach AN, Demidenko E, Owens P, Faber AC, Golub TR, Straussman R, Miller TW.
Shee K, et al. Among authors: hampsch ra.
J Exp Med. 2018 Mar 5;215(3):895-910. doi: 10.1084/jem.20171818. Epub 2018 Feb 7.
J Exp Med. 2018.
PMID: 29436393
Free PMC article.
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Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer.
Hosford SR, Shee K, Wells JD, Traphagen NA, Fields JL, Hampsch RA, Kettenbach AN, Demidenko E, Miller TW.
Hosford SR, et al. Among authors: hampsch ra.
Mol Oncol. 2019 Aug;13(8):1778-1794. doi: 10.1002/1878-0261.12528. Epub 2019 Jul 9.
Mol Oncol. 2019.
PMID: 31180176
Free PMC article.
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Tumour, whole-blood, plasma and tissue concentrations of metformin in lung cancer patients.
Phillips JD, Pooler DB, Ness DB, Fay K, Tau S, Demidenko E, Hampsch RA, Lewis LD, Miller TW.
Phillips JD, et al. Among authors: hampsch ra.
Br J Clin Pharmacol. 2023 Mar;89(3):1027-1035. doi: 10.1111/bcp.15546. Epub 2022 Oct 12.
Br J Clin Pharmacol. 2023.
PMID: 36164710
Free PMC article.
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