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Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor.
Paparin JL, Amador A, Badaroux E, Bot S, Caillet C, Convard T, Da Costa D, Dukhan D, Griffe L, Griffon JF, LaColla M, Leroy F, Liuzzi M, Giulia Loi A, McCarville J, Mascia V, Milhau J, Onidi L, Pierra C, Rahali R, Rosinosky E, Sais E, Seifer M, Surleraux D, Standring D, Dousson CB. Paparin JL, et al. Among authors: pierra c. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2634-2640. doi: 10.1016/j.bmcl.2017.01.017. Epub 2017 Jan 13. Bioorg Med Chem Lett. 2017. PMID: 28416131
Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.
Sizun G, Pierra C, Peyronnet J, Badaroux E, Rabeson C, Benzaria-Prad S, Surleraux D, Loi AG, Musiu C, Liuzzi M, Seifer M, Standring D, Sommadossi JP, Gosselin G. Sizun G, et al. Among authors: pierra c. Future Med Chem. 2015;7(13):1675-700. doi: 10.4155/fmc.15.96. Epub 2015 Oct 1. Future Med Chem. 2015. PMID: 26424162
Synthesis of beta-L-2'-deoxythymidine (L-dT).
Pierra C, Dukhan D, Gosselin G, Sommadossi JP. Pierra C, et al. Curr Protoc Nucleic Acid Chem. 2006 Apr;Chapter 14:Unit 14.3. doi: 10.1002/0471142700.nc1403s24. Curr Protoc Nucleic Acid Chem. 2006. PMID: 18428950
2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.
Benzaria S, Bardiot D, Bouisset T, Counor C, Rabeson C, Pierra C, Storer R, Loi AG, Cadeddu A, Mura M, Musiu C, Liuzzi M, Loddo R, Bergelson S, Bichko V, Bridges E, Cretton-Scott E, Mao J, Sommadossi JP, Seifer M, Standring D, Tausek M, Gosselin G, La Colla P. Benzaria S, et al. Among authors: pierra c. Antivir Chem Chemother. 2007;18(4):225-42. doi: 10.1177/095632020701800406. Antivir Chem Chemother. 2007. PMID: 17907380 Free article.
4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides revisited.
Griffon JF, Dukhan D, Pierra C, Benzaria S, Loi AG, La Colla P, Sommadossi JP, Gosselin G. Griffon JF, et al. Among authors: pierra c. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):707-9. doi: 10.1081/NCN-120022615. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565259
37 results