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PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.
Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, Vazquez F, Widlund HR, Sabatini DM, Hahn WC. Ilic N, et al. Among authors: widlund hr. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10. Proc Natl Acad Sci U S A. 2017. PMID: 28396387 Free PMC article.
"Lineage addiction" in human cancer: lessons from integrated genomics.
Garraway LA, Weir BA, Zhao X, Widlund H, Beroukhim R, Berger A, Rimm D, Rubin MA, Fisher DE, Meyerson ML, Sellers WR. Garraway LA, et al. Cold Spring Harb Symp Quant Biol. 2005;70:25-34. doi: 10.1101/sqb.2005.70.016. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869735
An oncogenic role for ETV1 in melanoma.
Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA. Jané-Valbuena J, et al. Among authors: widlund hr. Cancer Res. 2010 Mar 1;70(5):2075-84. doi: 10.1158/0008-5472.CAN-09-3092. Epub 2010 Feb 16. Cancer Res. 2010. PMID: 20160028 Free PMC article.
A PGC1α-mediated transcriptional axis suppresses melanoma metastasis.
Luo C, Lim JH, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P. Luo C, et al. Among authors: widlund hr. Nature. 2016 Sep 15;537(7620):422-426. doi: 10.1038/nature19347. Epub 2016 Aug 31. Nature. 2016. PMID: 27580028 Free PMC article.
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.
Scott KL, Kabbarah O, Liang MC, Ivanova E, Anagnostou V, Wu J, Dhakal S, Wu M, Chen S, Feinberg T, Huang J, Saci A, Widlund HR, Fisher DE, Xiao Y, Rimm DL, Protopopov A, Wong KK, Chin L. Scott KL, et al. Among authors: widlund hr. Nature. 2009 Jun 25;459(7250):1085-90. doi: 10.1038/nature08109. Nature. 2009. PMID: 19553991 Free PMC article.
Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF.
Feige E, Yokoyama S, Levy C, Khaled M, Igras V, Lin RJ, Lee S, Widlund HR, Granter SR, Kung AL, Fisher DE. Feige E, et al. Among authors: widlund hr. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E924-33. doi: 10.1073/pnas.1106351108. Epub 2011 Sep 26. Proc Natl Acad Sci U S A. 2011. PMID: 21949374 Free PMC article.
59 results