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The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs.
Feng C, Zhang Y, Yang M, Lan M, Liu H, Wang J, Zhou Y, Huang B. Feng C, et al. Among authors: zhou y. Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):220-230. doi: 10.1016/j.bbadis.2016.10.011. Epub 2016 Oct 19. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27769935 Free article.
Collagen-derived N-acetylated proline-glycine-proline upregulates the expression of pro-inflammatory cytokines and extracellular matrix proteases in nucleus pulposus cells via the NF-κB and MAPK signaling pathways.
Feng C, He J, Zhang Y, Lan M, Yang M, Liu H, Huang B, Pan Y, Zhou Y. Feng C, et al. Among authors: zhou y. Int J Mol Med. 2017 Jul;40(1):164-174. doi: 10.3892/ijmm.2017.3005. Epub 2017 May 29. Int J Mol Med. 2017. PMID: 28560408 Free PMC article.
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