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Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes.
Kilpatrick LE, Friedman-Ohana R, Alcobia DC, Riching K, Peach CJ, Wheal AJ, Briddon SJ, Robers MB, Zimmerman K, Machleidt T, Wood KV, Woolard J, Hill SJ. Kilpatrick LE, et al. Among authors: friedman ohana r. Biochem Pharmacol. 2017 Jul 15;136:62-75. doi: 10.1016/j.bcp.2017.04.006. Epub 2017 Apr 7. Biochem Pharmacol. 2017. PMID: 28392095 Free PMC article.
The luminescent HiBiT peptide enables selective quantitation of G protein-coupled receptor ligand engagement and internalization in living cells.
Boursier ME, Levin S, Zimmerman K, Machleidt T, Hurst R, Butler BL, Eggers CT, Kirkland TA, Wood KV, Friedman Ohana R. Boursier ME, et al. Among authors: friedman ohana r. J Biol Chem. 2020 Apr 10;295(15):5124-5135. doi: 10.1074/jbc.RA119.011952. Epub 2020 Feb 27. J Biol Chem. 2020. PMID: 32107310 Free PMC article.
Quantifying Target Occupancy of Small Molecules Within Living Cells.
Robers MB, Friedman-Ohana R, Huber KVM, Kilpatrick L, Vasta JD, Berger BT, Chaudhry C, Hill S, Müller S, Knapp S, Wood KV. Robers MB, et al. Among authors: friedman ohana r. Annu Rev Biochem. 2020 Jun 20;89:557-581. doi: 10.1146/annurev-biochem-011420-092302. Epub 2020 Mar 24. Annu Rev Biochem. 2020. PMID: 32208767 Review.
Development of a dehalogenase-based protein fusion tag capable of rapid, selective and covalent attachment to customizable ligands.
Encell LP, Friedman Ohana R, Zimmerman K, Otto P, Vidugiris G, Wood MG, Los GV, McDougall MG, Zimprich C, Karassina N, Learish RD, Hurst R, Hartnett J, Wheeler S, Stecha P, English J, Zhao K, Mendez J, Benink HA, Murphy N, Daniels DL, Slater MR, Urh M, Darzins A, Klaubert DH, Bulleit RF, Wood KV. Encell LP, et al. Curr Chem Genomics. 2012;6:55-71. doi: 10.2174/1875397301206010055. Epub 2012 Oct 5. Curr Chem Genomics. 2012. PMID: 23248739 Free PMC article.
14 results