Unexpected reactivity of 2-fluorolinalyl diphosphate in the active site of crystalline 2-methylisoborneol synthase.
Köksal M, Chou WK, Cane DE, Christianson DW.
Köksal M, et al.
Biochemistry. 2013 Aug 6;52(31):5247-55. doi: 10.1021/bi400797c. Epub 2013 Jul 22.
Biochemistry. 2013.
PMID: 23844678
Free PMC article.
MIBS does not exhibit catalytic activity with 2-fluorogeranyl diphosphate, and we recently reported the crystal structure of MIBS complexed with this unreactive substrate analogue [ Koksal, M., Chou, W. K. W., Cane, D. E., Christianson, D. W. (2012) Biochemistry 51 …
MIBS does not exhibit catalytic activity with 2-fluorogeranyl diphosphate, and we recently reported the crystal structure of MIBS complexed …