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Unexpected reactivity of 2-fluorolinalyl diphosphate in the active site of crystalline 2-methylisoborneol synthase.
Köksal M, Chou WK, Cane DE, Christianson DW. Köksal M, et al. Biochemistry. 2013 Aug 6;52(31):5247-55. doi: 10.1021/bi400797c. Epub 2013 Jul 22. Biochemistry. 2013. PMID: 23844678 Free PMC article.
MIBS does not exhibit catalytic activity with 2-fluorogeranyl diphosphate, and we recently reported the crystal structure of MIBS complexed with this unreactive substrate analogue [ Koksal, M., Chou, W. K. W., Cane, D. E., Christianson, D. W. (2012) Biochemistry 51 …
MIBS does not exhibit catalytic activity with 2-fluorogeranyl diphosphate, and we recently reported the crystal structure of MIBS complexed …
Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence.
Harris GG, Lombardi PM, Pemberton TA, Matsui T, Weiss TM, Cole KE, Köksal M, Murphy FV 4th, Vedula LS, Chou WK, Cane DE, Christianson DW. Harris GG, et al. Among authors: koksal m. Biochemistry. 2015 Dec 8;54(48):7142-55. doi: 10.1021/acs.biochem.5b01143. Epub 2015 Nov 24. Biochemistry. 2015. PMID: 26598179 Free PMC article.
114 results