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SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.
Albornoz EA, Amarilla AA, Modhiran N, Parker S, Li XX, Wijesundara DK, Aguado J, Zamora AP, McMillan CLD, Liang B, Peng NYG, Sng JDJ, Saima FT, Fung JN, Lee JD, Paramitha D, Parry R, Avumegah MS, Isaacs A, Lo MW, Miranda-Chacon Z, Bradshaw D, Salinas-Rebolledo C, Rajapakse NW, Wolvetang EJ, Munro TP, Rojas-Fernandez A, Young PR, Stacey KJ, Khromykh AA, Chappell KJ, Watterson D, Woodruff TM. Albornoz EA, et al. Among authors: rojas fernandez a. Mol Psychiatry. 2023 Jul;28(7):2878-2893. doi: 10.1038/s41380-022-01831-0. Epub 2022 Nov 1. Mol Psychiatry. 2023. PMID: 36316366 Free PMC article.
Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody.
Valenzuela Nieto G, Jara R, Watterson D, Modhiran N, Amarilla AA, Himelreichs J, Khromykh AA, Salinas-Rebolledo C, Pinto T, Cheuquemilla Y, Margolles Y, López González Del Rey N, Miranda-Chacon Z, Cuevas A, Berking A, Deride C, González-Moraga S, Mancilla H, Maturana D, Langer A, Toledo JP, Müller A, Uberti B, Krall P, Ehrenfeld P, Blesa J, Chana-Cuevas P, Rehren G, Schwefel D, Fernandez LÁ, Rojas-Fernandez A. Valenzuela Nieto G, et al. Among authors: rojas fernandez a. Sci Rep. 2021 Feb 8;11(1):3318. doi: 10.1038/s41598-021-82833-w. Sci Rep. 2021. PMID: 33558635 Free PMC article.
SUMO chain-induced dimerization activates RNF4.
Rojas-Fernandez A, Plechanovová A, Hattersley N, Jaffray E, Tatham MH, Hay RT. Rojas-Fernandez A, et al. Mol Cell. 2014 Mar 20;53(6):880-92. doi: 10.1016/j.molcel.2014.02.031. Mol Cell. 2014. PMID: 24656128 Free PMC article.
The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport.
Bustamante HA, Cereceda K, González AE, Valenzuela GE, Cheuquemilla Y, Hernández S, Arias-Muñoz E, Cerda-Troncoso C, Bandau S, Soza A, Kausel G, Kerr B, Mardones GA, Cancino J, Hay RT, Rojas-Fernandez A, Burgos PV. Bustamante HA, et al. Cells. 2020 Mar 23;9(3):777. doi: 10.3390/cells9030777. Cells. 2020. PMID: 32210007 Free PMC article.
22 results