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CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.
Zaghloul EM, Gissberg O, Moreno PMD, Siggens L, Hällbrink M, Jørgensen AS, Ekwall K, Zain R, Wengel J, Lundin KE, Smith CIE. Zaghloul EM, et al. Among authors: wengel j. Nucleic Acids Res. 2017 May 19;45(9):5153-5169. doi: 10.1093/nar/gkx111. Nucleic Acids Res. 2017. PMID: 28334749 Free PMC article.
Structural characterization of LNA and alpha-L-LNA hybridized to RNA.
Petersen M, Nielsen JT, Bondensgaard K, Wengel J, Jacobsen JP. Petersen M, et al. Among authors: wengel j. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1691-3. doi: 10.1081/NCN-120023115. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565497
New conformationally restricted DNA mimics.
Højland T, Babu BR, Wengel J. Højland T, et al. Among authors: wengel j. Nucleic Acids Symp Ser (Oxf). 2008;(52):271-2. doi: 10.1093/nass/nrn137. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776358
A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjær N, Odadzic D, Smicius R, Wengel SL, Chattopadhyaya J, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: wengel j, wengel sl. Nucleic Acids Res. 2010 Sep;38(17):5761-73. doi: 10.1093/nar/gkq341. Epub 2010 May 7. Nucleic Acids Res. 2010. PMID: 20453030 Free PMC article.
299 results