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Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene.
Xu T, Cheng D, Zhao Y, Zhang J, Zhu X, Zhang F, Chen G, Wang Y, Yan X, Robertson GP, Gaddameedhi S, Lazarus P, Wang S, Zhu J. Xu T, et al. Among authors: wang y, wang s. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2019043118. doi: 10.1073/pnas.2019043118. Proc Natl Acad Sci U S A. 2021. PMID: 34155099 Free PMC article.
Dual roles of c-Myc in the regulation of hTERT gene.
Zhao Y, Cheng D, Wang S, Zhu J. Zhao Y, et al. Among authors: wang s. Nucleic Acids Res. 2014;42(16):10385-98. doi: 10.1093/nar/gku721. Epub 2014 Aug 28. Nucleic Acids Res. 2014. PMID: 25170084 Free PMC article.
Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes.
Cheng D, Zhao Y, Wang S, Zhang F, Russo M, McMahon SB, Zhu J. Cheng D, et al. Among authors: wang s. FASEB J. 2017 Mar;31(3):1165-1178. doi: 10.1096/fj.201601111R. Epub 2016 Dec 9. FASEB J. 2017. PMID: 27940549 Free PMC article.
Together, our data indicate that the lack of telomerase expression in most human somatic cells results from its repressive genomic environment, providing new insight into the mechanism of long-recognized differential telomerase regulation in mammalian species.-Cheng, D., Zhao, Y. …
Together, our data indicate that the lack of telomerase expression in most human somatic cells results from its repressive genomic environme …
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