Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes.
Cheng D, Zhao Y, Wang S, Zhang F, Russo M, McMahon SB, Zhu J.
Cheng D, et al. Among authors: wang s.
FASEB J. 2017 Mar;31(3):1165-1178. doi: 10.1096/fj.201601111R. Epub 2016 Dec 9.
FASEB J. 2017.
PMID: 27940549
Free PMC article.
Together, our data indicate that the lack of telomerase expression in most human somatic cells results from its repressive genomic environment, providing new insight into the mechanism of long-recognized differential telomerase regulation in mammalian species.-Cheng, D., Zhao, Y. …
Together, our data indicate that the lack of telomerase expression in most human somatic cells results from its repressive genomic environme …