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EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.
Mohammad F, Weissmann S, Leblanc B, Pandey DP, Højfeldt JW, Comet I, Zheng C, Johansen JV, Rapin N, Porse BT, Tvardovskiy A, Jensen ON, Olaciregui NG, Lavarino C, Suñol M, de Torres C, Mora J, Carcaboso AM, Helin K. Mohammad F, et al. Among authors: rapin n. Nat Med. 2017 Apr;23(4):483-492. doi: 10.1038/nm.4293. Epub 2017 Feb 27. Nat Med. 2017. PMID: 28263309
Initiation of MLL-rearranged AML is dependent on C/EBPα.
Ohlsson E, Hasemann MS, Willer A, Lauridsen FK, Rapin N, Jendholm J, Porse BT. Ohlsson E, et al. Among authors: rapin n. J Exp Med. 2014 Jan 13;211(1):5-13. doi: 10.1084/jem.20130932. Epub 2013 Dec 23. J Exp Med. 2014. PMID: 24367003 Free PMC article.
C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors.
Hasemann MS, Lauridsen FK, Waage J, Jakobsen JS, Frank AK, Schuster MB, Rapin N, Bagger FO, Hoppe PS, Schroeder T, Porse BT. Hasemann MS, et al. Among authors: rapin n. PLoS Genet. 2014 Jan;10(1):e1004079. doi: 10.1371/journal.pgen.1004079. Epub 2014 Jan 9. PLoS Genet. 2014. PMID: 24415956 Free PMC article.
Cellular origin of prognostic chromosomal aberrations in AML patients.
Mora-Jensen H, Jendholm J, Rapin N, Andersen MK, Roug AS, Bagger FO, Bullinger L, Winther O, Borregaard N, Porse BT, Theilgaard-Mönch K. Mora-Jensen H, et al. Among authors: rapin n. Leukemia. 2015 Aug;29(8):1785-9. doi: 10.1038/leu.2015.30. Epub 2015 Feb 11. Leukemia. 2015. PMID: 25670329 No abstract available.
72 results