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Novel hydroxamates potentiated in vitro activity of fluconazole against Candida albicans.
Paul-Satyaseela M, Hariharan P, Bharani T, Franklyne JS, Selvakumar T, Bharathimohan K, Kumar CV, Kachhadia V, Narayanan S, Rajagopal S, Balasubramanian G. Paul-Satyaseela M, et al. Among authors: rajagopal s. J Nat Sci Biol Med. 2017 Jan-Jun;8(1):119-124. doi: 10.4103/0976-9668.198349. J Nat Sci Biol Med. 2017. PMID: 28250687 Free PMC article.
Discovery of adamantane based highly potent HDAC inhibitors.
Gopalan B, Ponpandian T, Kachhadia V, Bharathimohan K, Vignesh R, Sivasudar V, Narayanan S, Mandar B, Praveen R, Saranya N, Rajagopal S, Rajagopal S. Gopalan B, et al. Among authors: rajagopal s. Bioorg Med Chem Lett. 2013 May 1;23(9):2532-7. doi: 10.1016/j.bmcl.2013.03.002. Epub 2013 Mar 14. Bioorg Med Chem Lett. 2013. PMID: 23538115
Quinolone-based HDAC inhibitors.
Balasubramanian G, Kilambi N, Rathinasamy S, Rajendran P, Narayanan S, Rajagopal S. Balasubramanian G, et al. Among authors: rajagopal s. J Enzyme Inhib Med Chem. 2014 Aug;29(4):555-62. doi: 10.3109/14756366.2013.827675. Epub 2013 Sep 9. J Enzyme Inhib Med Chem. 2014. PMID: 25019596
Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.
Kachhadia V, Rajagopal S, Ponpandian T, Vignesh R, Anandhan K, Prabhu D, Rajendran P, Nidhyanandan S, Roy AM, Ahamed FA, Surendran N, Rajagopal S, Narayanan S, Gopalan B. Kachhadia V, et al. Among authors: rajagopal s. Eur J Med Chem. 2016 Jan 27;108:274-286. doi: 10.1016/j.ejmech.2015.11.014. Epub 2015 Nov 19. Eur J Med Chem. 2016. PMID: 26689485
In vivo effective dibenzo[b,d]furan-1-yl-thiazoles as novel PDE-4 inhibitors.
Balasubramanian G, Narayanan S, Andiappan L, Sappanimuthu T, Thirunavukkarasu S, Sundaram S, Natarajan S, Sivaraman N, Rajagopal S, Nazumudeen FAA, Saxena S, Vishwakarma SL, Narayanan S, Sharma GVR, Srinivasan CV, Kilambi N. Balasubramanian G, et al. Among authors: rajagopal s. Bioorg Med Chem. 2016 Nov 15;24(22):5702-5716. doi: 10.1016/j.bmc.2016.09.011. Epub 2016 Sep 9. Bioorg Med Chem. 2016. PMID: 27713015
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.
Ruf S, Hallur MS, Anchan NK, Swamy IN, Murugesan KR, Sarkar S, Narasimhulu LK, Putta VPRK, Shaik S, Chandrasekar DV, Mane VS, Kadnur SV, Suresh J, Bhamidipati RK, Singh M, Burri RR, Kristam R, Schreuder H, Czech J, Rudolph C, Marker A, Langer T, Mullangi R, Yura T, Gosu R, Kannt A, Dhakshinamoorthy S, Rajagopal S. Ruf S, et al. Among authors: rajagopal s. Bioorg Med Chem Lett. 2018 Mar 1;28(5):922-925. doi: 10.1016/j.bmcl.2018.01.058. Epub 2018 Jan 31. Bioorg Med Chem Lett. 2018. PMID: 29433927
Validation of an LC-MS/MS method for simultaneous detection of four HDAC inhibitors - belinostat, panobinostat, rocilinostat and vorinostat in mouse plasma and its application to a mouse pharmacokinetic study.
Giri KK, Suresh PS, Saim SM, Zainuddin M, Bhamidipati RK, Dewang P, Hallur MS, Rajagopal S, Rajagopal S, Mullangi R. Giri KK, et al. Among authors: rajagopal s. Biomed Chromatogr. 2017 Jul;31(7). doi: 10.1002/bmc.3912. Epub 2017 Jan 22. Biomed Chromatogr. 2017. PMID: 27925271
Novel dual LSD1/HDAC6 inhibitors for the treatment of multiple myeloma.
Naveen Sadhu M, Sivanandhan D, Gajendran C, Tantry S, Dewang P, Murugan K, Chickamunivenkatappa S, Zainuddin M, Nair S, Vaithilingam K, Rajagopal S. Naveen Sadhu M, et al. Among authors: rajagopal s. Bioorg Med Chem Lett. 2021 Feb 15;34:127763. doi: 10.1016/j.bmcl.2020.127763. Epub 2020 Dec 24. Bioorg Med Chem Lett. 2021. PMID: 33359604
580 results