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PelA and PelB proteins form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation in Pseudomonas aeruginosa.
Marmont LS, Whitfield GB, Rich JD, Yip P, Giesbrecht LB, Stremick CA, Whitney JC, Parsek MR, Harrison JJ, Howell PL. Marmont LS, et al. Among authors: rich jd. J Biol Chem. 2017 Nov 24;292(47):19411-19422. doi: 10.1074/jbc.M117.812842. Epub 2017 Sep 27. J Biol Chem. 2017. PMID: 28972168 Free PMC article.
Bacterial cyclic diguanylate signaling networks sense temperature.
Almblad H, Randall TE, Liu F, Leblanc K, Groves RA, Kittichotirat W, Winsor GL, Fournier N, Au E, Groizeleau J, Rich JD, Lou Y, Granton E, Jennings LK, Singletary LA, Winstone TML, Good NM, Bumgarner RE, Hynes MF, Singh M, Stietz MS, Brinkman FSL, Kumar A, Brassinga AKC, Parsek MR, Tseng BS, Lewis IA, Yipp BG, MacCallum JL, Harrison JJ. Almblad H, et al. Among authors: rich jd. Nat Commun. 2021 Mar 31;12(1):1986. doi: 10.1038/s41467-021-22176-2. Nat Commun. 2021. PMID: 33790266 Free PMC article.
Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence.
Razvi E, Whitfield GB, Reichhardt C, Dreifus JE, Willis AR, Gluscencova OB, Gloag ES, Awad TS, Rich JD, da Silva DP, Bond W, Le Mauff F, Sheppard DC, Hatton BD, Stoodley P, Reinke AW, Boulianne GL, Wozniak DJ, Harrison JJ, Parsek MR, Howell PL. Razvi E, et al. Among authors: rich jd. NPJ Biofilms Microbiomes. 2023 Feb 2;9(1):7. doi: 10.1038/s41522-023-00375-7. NPJ Biofilms Microbiomes. 2023. PMID: 36732330 Free PMC article.
Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation.
Razvi E, DiFrancesco BR, Wasney GA, Morrison ZA, Tam J, Auger A, Baker P, Alnabelseya N, Rich JD, Sivarajah P, Whitfield GB, Harrison JJ, Melnyk RA, Nitz M, Howell PL. Razvi E, et al. Among authors: rich jd. Microbiol Spectr. 2023 Jun 15;11(3):e0029623. doi: 10.1128/spectrum.00296-23. Epub 2023 Apr 26. Microbiol Spectr. 2023. PMID: 37098898 Free PMC article.
Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection.
Granton E, Brown L, Defaye M, Moazen P, Almblad H, Randall TE, Rich JD, Geppert A, Abdullah NS, Hassanabad MF, Hiroki CH, Farias R, Nguyen AP, Schubert C, Lou Y, Andonegui G, Iftinca M, Raju D, Vargas MA, Howell PL, Füzesi T, Bains J, Kurrasch D, Harrison JJ, Altier C, Yipp BG. Granton E, et al. Among authors: rich jd. Cell. 2024 Apr 11;187(8):1874-1888.e14. doi: 10.1016/j.cell.2024.03.001. Epub 2024 Mar 21. Cell. 2024. PMID: 38518773
411 results